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atoS [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 949011, updated on 11-Sep-2024

Summary

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Official Symbol
atoS
Primary source
ECOCYC:EG11667
Locus tag
b2219
See related
ASAP:ABE-0007341
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2212
Summary
AtoS belongs to the two component systems AtoS/AtoC that responds to growth in minimal media . [More information is available at EcoCyc: EG11667].
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Genomic context

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Sequence:
NC_000913.3 (2320043..2321869)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional activator RcsB Neighboring gene histidine kinase RcsC Neighboring gene DNA-binding transcriptional activator/ornithine decarboxylase inhibitor AtoC Neighboring gene acetyl-CoA:acetoacetyl-CoA transferase subunit alpha Neighboring gene acetyl-CoA:acetoacetyl-CoA transferase subunit beta Neighboring gene short chain fatty acid transporter

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional characterization of the histidine kinase of the E. coli two-component signal transduction system AtoS-AtoC. Filippou PS, et al. Biochim Biophys Acta, 2008 Sep. PMID 18534200
  2. The soul of an HMO. Larson E. Time, 1996 Jan 22. PMID 10153782
  3. AtoSC two-component system is involved in cPHB biosynthesis through fatty acid metabolism in E. coli. Theodorou EC, et al. Biochim Biophys Acta, 2011 May. PMID 21295116
  4. Activation of the AtoSC two-component system in the absence of the AtoC N-terminal receiver domain in E. coli. Theodorou EC, et al. Amino Acids, 2011 Feb. PMID 20563612
  5. Extracellular Ca2+ transients affect poly-(R)-3-hydroxybutyrate regulation by the AtoS-AtoC system in Escherichia coli. Theodorou MC, et al. Biochem J, 2009 Feb 1. PMID 18855762

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data indicate that the involvement of the AtoSC system in the fatty acids metabolic pathways interplay towards cPHB biosynthesis provides additional perceptions of AtoSC role on E. coli regulatory biochemical processes.
    Title: AtoSC two-component system is involved in cPHB biosynthesis through fatty acid metabolism in E. coli.
  2. AtoC N-terminal receiver domain regulated the biological activities of AtoSC.
    Title: Activation of the AtoSC two-component system in the absence of the AtoC N-terminal receiver domain in E. coli.
  3. Effect of histamine on the signal transduction of the AtoS-AtoC two component system and involvement in poly-(R)-3-hydroxybutyrate biosynthesis in Escherichia coli.(
    Title: Effect of histamine on the signal transduction of the AtoS-AtoC two component system and involvement in poly-(R)-3-hydroxybutyrate biosynthesis in Escherichia coli.
  4. AtoS is a membrane protein which can autophosphorylate & then transfer that phosphoryl group to AtoC. Gene products of atoS & atoC constitute a 2-component signal transduction system, with some unusual properties, involved in regulation of atoDAEB operon.
    Title: Phosphorylation activity of the response regulator of the two-component signal transduction system AtoS-AtoC in E. coli.
  5. These results indicate that the presence of both a functional AtoS-AtoC two-component signal transduction system and a functional atoDAEB operon is critical for the enhanced poly-(R)-3-hydroxybutyrate cPHB biosynthesis in E. coli.
    Title: Involvement of the AtoS-AtoC signal transduction system in poly-(R)-3-hydroxybutyrate biosynthesis in Escherichia coli.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphorelay sensor kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphorelay sensor kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein histidine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in phosphorelay signal transduction system IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to polyamine macromolecule IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
sensor histidine kinase AtoS
NP_416723.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2320043..2321869
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416723.1 sensor histidine kinase AtoS [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416723.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2H4TXE0, A0A3P5DQW9
    Conserved Domains (1) summary
    PRK11360
    Location:7 → 606
    PRK11360; two-component system sensor histidine kinase AtoS
Nucleotide Protein
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