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caiD crotonobetainyl-CoA hydratase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948995, updated on 19-Sep-2024

Summary

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Official Symbol
caiD
Official Full Name
crotonobetainyl-CoA hydratase
Primary source
ECOCYC:EG11557
Locus tag
b0036
See related
ASAP:ABE-0000130
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0037; yaaL
Summary
Uses gamma-butyrobetainyl-CoA as co-factor. [More information is available at EcoGene: EG11557]. CaiD is a member of the crotonase superfamily; the enzyme purified from Escherichia coli O44:K74 catalyzes the hydration of crotonobetainyl-CoA to carnitinyl-CoA and can use crotonyl-CoA, but not crotonobetaine, as an alternative substrate . [More information is available at EcoCyc: EG11557].
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Genomic context

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Sequence:
NC_000913.3 (35377..36162, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional activator CaiF Neighboring gene putative transferase CaiE Neighboring gene carnitine--CoA ligase Neighboring gene gamma-butyrobetainyl-CoA:carnitine CoA transferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. [Cloning and expression of caiDE genes in E. coli BL21(DE3)]. Jiang J, et al. Wei Sheng Wu Xue Bao, 2000 Dec. PMID 12549051
  2. Isolation, identification, and synthesis of gamma-butyrobetainyl-CoA and crotonobetainyl-CoA, compounds involved in carnitine metabolism of E. coli. Elssner T, et al. Biochemistry, 2000 Sep 5. PMID 10978161
  3. Role of wet experiment design in data generation: from in vivo to in silico and back. Cánovas M, et al. In Silico Biol, 2007. PMID 17822388
  4. Regulation of the carnitine pathway in Escherichia coli: investigation of the cai-fix divergent promoter region. Buchet A, et al. J Bacteriol, 1998 May. PMID 9573142, Free PMC Article
  5. Identification and characterization of the caiF gene encoding a potential transcriptional activator of carnitine metabolism in Escherichia coli. Eichler K, et al. J Bacteriol, 1996 Mar. PMID 8631699, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables L-carnitine CoA-transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables carnitine racemase activity EXP
Inferred from Experiment
more info
 PubMed 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables crotonyl-CoA hydratase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydro-lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within carnitine catabolic process EXP
Inferred from Experiment
more info
 PubMed 
involved_in carnitine metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid beta-oxidation IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
crotonobetainyl-CoA hydratase
NP_414578.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    35377..36162 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414578.2 crotonobetainyl-CoA hydratase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414578.2

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2X1N2R8, A0A831DY24
    Conserved Domains (1) summary
    PRK03580
    Location:1 → 261
    PRK03580; crotonobetainyl-CoA hydratase
Nucleotide Protein
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