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hycD hydrogenase 3 membrane subunit HycD [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948994, updated on 3-Jun-2026
Official Symbol
hycD
Official Full Name
hydrogenase 3 membrane subunit HycD
Primary source
ECOCYC:EG10477
Locus tag
b2722
See related
ASAP:ABE-0008946
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2717; hevD
Summary
FhlA regulon. [More information is available at EcoGene: EG10477]. HycD encodes an extremely hydrophobic protein with 8 predicted transmembrane domains. [More information is available at EcoCyc: EG10477].
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Sequence:
NC_000913.3 (2846489..2847412, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene hydrogenase 3 Neighboring gene hydrogenase 3 Neighboring gene hydrogenase 3 large subunit Neighboring gene hydrogenase 3 membrane subunit HycC Neighboring gene hydrogenase 3 Neighboring gene regulator of the transcriptional regulator FhlA

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Microbial reduction of technetium by Escherichia coli and Desulfovibrio desulfuricans: enhancement via the use of high-activity strains and effect of process parameters. Lloyd JR, et al. Biotechnol Bioeng, 1999. PMID 10567070
  2. Reduction and removal of heptavalent technetium from solution by Escherichia coli. Lloyd JR, et al. J Bacteriol, 1997 Mar. PMID 9068649, Free PMC Article
  3. Regulation of gene expression in fermentative and respiratory systems in Escherichia coli and related bacteria. Lin EC, et al. Annu Rev Genet, 1991. PMID 1812811
  4. Regulated expression in vitro of genes coding for formate hydrogenlyase components of Escherichia coli. Hopper S, et al. J Biol Chem, 1994 Jul 29. PMID 8034728
  5. Global gene expression profiling in Escherichia coli K12: effects of oxygen availability and ArcA. Salmon KA, et al. J Biol Chem, 2005 Apr 15. PMID 15699038

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Process Evidence Code Pubs
involved_in anaerobic electron transport chain IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in anaerobic electron transport chain IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in anaerobic respiration IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in formate oxidation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glucose catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of formate dehydrogenase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of formate dehydrogenase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Preferred Names
hydrogenase 3 membrane subunit HycD
NP_417202.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2846489..2847412 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417202.1 hydrogenase 3 membrane subunit HycD

    See identical proteins and their annotated locations for NP_417202.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A376FZC4
    Conserved Domains (1) summary
    COG0650
    Location:1 → 306
    HyfC; Formate hydrogenlyase subunit 4 [Energy production and conversion]
Nucleotide Protein
Heading Accession and Version

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