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lolA outer membrane lipoprotein carrier protein [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948989, updated on 3-Dec-2024

Summary

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Official Symbol
lolA
Official Full Name
outer membrane lipoprotein carrier protein
Primary source
ECOCYC:G6465
Locus tag
b0891
See related
ASAP:ABE-0003031
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0882; lplA; yzzV
Summary
Lipoproteins contain a fatty acyl chain covalently attached to the N-terminal cysteine residue. [More information is available at EcoCyc: G6465].
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Genomic context

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Sequence:
NC_000913.3 (937372..937983)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional dual regulator Lrp Neighboring gene cell division DNA translocase FtsK Neighboring gene replication-associated recombination protein A Neighboring gene serine--tRNA ligase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Lipoprotein sorting signals evaluated as the LolA-dependent release of lipoproteins from the cytoplasmic membrane of Escherichia coli. Terada M, et al. J Biol Chem, 2001 Dec 14. PMID 11592971
  2. Defective lipoprotein sorting induces lolA expression through the Rcs stress response phosphorelay system. Tao K, et al. J Bacteriol, 2012 Jul. PMID 22563052, Free PMC Article
  3. Backbone resonance assignments for the periplasmic chaperone LolA from Escherichia coli. Nakada S, et al. Biomol NMR Assign, 2007 Jul. PMID 19636845
  4. A new screening method to identify inhibitors of the Lol (localization of lipoproteins) system, a novel antibacterial target. Ito H, et al. Microbiol Immunol, 2007. PMID 17380045
  5. A short helix in the C-terminal region of LolA is important for the specific membrane localization of lipoproteins. Okuda S, et al. FEBS Lett, 2008 Jun 25. PMID 18503771

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Crystal structures of human lysosomal EPDR1 reveal homology with the superfamily of bacterial lipoprotein transporters, such as LolA.
    Title: Crystal structures of human lysosomal EPDR1 reveal homology with the superfamily of bacterial lipoprotein transporters.
  2. The correct lipoprotein sorting by lolA to the outer membrane is monitored by RcsF, which plays a key role in the Rcs stress response system.
    Title: Defective lipoprotein sorting induces lolA expression through the Rcs stress response phosphorelay system.
  3. PulD protomers normally cross the periplasm together with PulS bound to LolA but when the latter cannot be separated (due to the mutation in lolA), the PulD protomers form dodecamers that insert into the inner membrane.
    Title: Sorting of an integral outer membrane protein via the lipoprotein-specific Lol pathway and a dedicated lipoprotein pilotin.
  4. kinetic parameters of lipoprotein transfer from LolA to LolB were determined
    Title: Real time analysis of lipoprotein transfer from LolA to LolB by means of surface plasmon resonance.
  5. the modified weighed Chemical-Shift Index (CSI) method suggested that the secondary structure of LolA in solution generally corresponded to that in the crystal structure
    Title: Backbone resonance assignments for the periplasmic chaperone LolA from Escherichia coli.
  6. interaction sites of LolA, LolB, and LolC which transfer lipoproteins
    Title: Model of mouth-to-mouth transfer of bacterial lipoproteins through inner membrane LolC, periplasmic LolA, and outer membrane LolB.
  7. The membrane localization of lipoproteins with the LolA derivative lacking the 3(10) helix was independent of LolB whereas LolB was essential for the outer membrane localization of lipoproteins with the wild-type LolA.
    Title: A short helix in the C-terminal region of LolA is important for the specific membrane localization of lipoproteins.
  8. We report here that the coexpression of LolA and outer membrane-specific lipoprotein Pal from a very efficient plasmid causes the unusual accumulation of the LolA-Pal complex in the periplasm.
    Title: Large-scale preparation of the homogeneous LolA lipoprotein complex and efficient in vitro transfer of lipoproteins to the outer membrane in a LolB-dependent manner.
  9. N-terminus verified by Edman degradation on mature peptide
    Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.
  10. analysis of roles of the hydrophobic cavity and lid of LolA in the lipoprotein transfer reaction in Escherichia coli
    Title: Roles of the hydrophobic cavity and lid of LolA in the lipoprotein transfer reaction in Escherichia coli.
Submit: New GeneRIF Correction See all GeneRIFs (11)

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in lipoprotein localization to outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipoprotein localization to outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in lipoprotein localization to outer membrane IEA
Inferred from Electronic Annotation
more info
  
involved_in lipoprotein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within lipoprotein transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in lipoprotein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in outer membrane-bounded periplasmic space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in outer membrane-bounded periplasmic space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in periplasmic space IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
outer membrane lipoprotein carrier protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    937372..937983
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415411.2 outer membrane lipoprotein carrier protein [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415411.2

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5D8MTT3, A0A9P2MM06
    Conserved Domains (1) summary
    TIGR00547
    Location:1 → 203
    lolA; periplasmic chaperone LolA
Nucleotide Protein
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