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hybD hydrogenase 2 maturation protease [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948982, updated on 23-Nov-2023

Summary

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Gene symbol
hybD
Gene description
hydrogenase 2 maturation protease
Primary source
ASAP:ABE-0009826
Locus tag
b2993
See related
ECOCYC:EG11802
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2987
Summary
Based on its similarity to the processing enzyme for hydrogenase 3, HycI, HybD is predicted to be an endopeptidase involved in the maturation of the large subunit of hydrogenase 2 (HybC) . [More information is available at EcoCyc: EG11802].
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Genomic context

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Sequence:
NC_000913.3 (3140792..3141286, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene hydrogenase maturation factor HybG Neighboring gene hydrogenase maturation protein HybF Neighboring gene hydrogenase 2-specific chaperone Neighboring gene hydrogenase 2 large subunit Neighboring gene hydrogenase 2 membrane subunit Neighboring gene hydrogenase 2 iron-sulfur protein Neighboring gene hydrogenase 2 small subunit

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Delimiting the Function of the C-Terminal Extension of the Escherichia coli [NiFe]-Hydrogenase 2 Large Subunit Precursor. Pinske C, et al. Front Microbiol, 2019. PMID 31611859, Free PMC Article
  2. Proteolytic cleavage orchestrates cofactor insertion and protein assembly in [NiFe]-hydrogenase biosynthesis. Senger M, et al. J Biol Chem, 2017 Jul 14. PMID 28539366, Free PMC Article
  3. Coordination of Synthesis and Assembly of a Modular Membrane-Associated [NiFe]-Hydrogenase Is Determined by Cleavage of the C-Terminal Peptide. Thomas C, et al. J Bacteriol, 2015 Sep. PMID 26170410, Free PMC Article
  4. Development of a cell-free system reveals an oxygen-labile step in the maturation of [NiFe]-hydrogenase 2 of Escherichia coli. Soboh B, et al. FEBS Lett, 2010 Sep 24. PMID 20807532
  5. Nickel serves as a substrate recognition motif for the endopeptidase involved in hydrogenase maturation. Theodoratou E, et al. Eur J Biochem, 2000 Apr. PMID 10727938

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables aspartic-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables endopeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables enzyme activator activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein processing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein processing IEA
Inferred from Electronic Annotation
more info
  
involved_in protein processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
hydrogenase 2 maturation protease

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3140792..3141286 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417467.1 hydrogenase 2 maturation protease [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417467.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A7L5V8B7
    Conserved Domains (1) summary
    PRK10466
    Location:1 → 164
    hybD; HyaD/HybD family hydrogenase maturation endopeptidase
Nucleotide Protein
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