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norV anaerobic nitric oxide reductase flavorubredoxin [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948979, updated on 30-Jul-2025
Official Symbol
norV
Official Full Name
anaerobic nitric oxide reductase flavorubredoxin
Primary source
ECOCYC:G7413
Locus tag
b2710
See related
ASAP:ABE-0008910
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2705; ygaI; ygaJ; ygaK
Summary
Upregulated by GSNO in defined medium. [More information is available at EcoGene: EG12963]. Flavorubredoxin (FlRd) is a multidomain protein containing an amino-terminal -lactamase-like module with a non-heme di-iron site as the catalytic center, a short chain flavodoxin-like module and a rubredoxin-like extension. [More information is available at EcoCyc: G7413].
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Sequence:
NC_000913.3 (2832476..2833915)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional repressor SrlR Neighboring gene D-arabinose 5-phosphate isomerase GutQ Neighboring gene DNA-binding transcriptional dual regulator NorR Neighboring gene NADH:flavorubredoxin reductase Neighboring gene carbamoyl-- Neighboring gene putative electron transport protein HydN

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Oxidative stress modulates the nitric oxide defense promoted by Escherichia coli flavorubredoxin. Baptista JM, et al. J Bacteriol, 2012 Jul. PMID 22563051, Free PMC Article
  2. Quaternary structure of flavorubredoxin as revealed by synchrotron radiation small-angle X-ray scattering. Petoukhov MV, et al. Structure, 2008 Sep 10. PMID 18786405
  3. Kinetic characterization of the Escherichia coli nitric oxide reductase flavorubredoxin. Vicente JB, et al. Methods Enzymol, 2008. PMID 18433622
  4. Kinetics of electron transfer from NADH to the Escherichia coli nitric oxide reductase flavorubredoxin. Vicente JB, et al. FEBS J, 2007 Feb. PMID 17181540
  5. Structure of Escherichia coli Flavodiiron Nitric Oxide Reductase. Romão CV, et al. J Mol Biol, 2016 Nov 20. PMID 27725182

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The overall tetrameric structure revealed a highly conserved flavodiiron core domain, with a metallo-beta-lactamase-like domain containing a diiron center, and a flavodoxin domain with a flavin mononucleotide cofactor.
    Title: Structure of Escherichia coli Flavodiiron Nitric Oxide Reductase.
  2. Rubredoxin binds nine TPR motifs to form LapB, an essential regulator of lipopolysaccharide synthesis.
    Title: An Unexpected Duo: Rubredoxin Binds Nine TPR Motifs to Form LapB, an Essential Regulator of Lipopolysaccharide Synthesis.
  3. Authors propose that the time-dependent activation of flavorubredoxin contributes to the adaptation of E. coli to the different fluxes of hydrogen peroxide and nitric oxide to which the bacterium is subjected during the course of macrophage infection.
    Title: Oxidative stress modulates the nitric oxide defense promoted by Escherichia coli flavorubredoxin.
  4. Quaternary structure of flavorubredoxin as revealed by synchrotron radiation small-angle X-ray scattering.
    Title: Quaternary structure of flavorubredoxin as revealed by synchrotron radiation small-angle X-ray scattering.
  5. the atypical glutamate does not guide metal selectivity of the FlRd metallo-beta-lactamase domain but suppresses possible hydrolytic cross-activity
    Title: Zinc- and iron-dependent cytosolic metallo-beta-lactamase domain proteins exhibit similar zinc-binding affinities, independent of an atypical glutamate at the metal-binding site.
  6. biochemical analyis of FlRd and its physiological partner, the NADH:flavorubredoxin oxidoreductase FlRd-Red
    Title: Redox and spectroscopic properties of the Escherichia coli nitric oxide-detoxifying system involving flavorubredoxin and its NADH-oxidizing redox partner.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables FMN binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables FMN binding IEA
Inferred from Electronic Annotation
more info
  
enables electron transfer activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables electron transfer activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables iron ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nitric oxide reductase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables nitric oxide reductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on other nitrogenous compounds as donors IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within nitric oxide catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to nitric oxide IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
anaerobic nitric oxide reductase flavorubredoxin

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2832476..2833915
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417190.1 anaerobic nitric oxide reductase flavorubredoxin

    See identical proteins and their annotated locations for NP_417190.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A376M547, A0A797LYQ3
    Conserved Domains (1) summary
    PRK05452
    Location:1 → 479
    PRK05452; anaerobic nitric oxide reductase flavorubredoxin; Provisional
Nucleotide Protein
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