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trpR DNA-binding transcriptional repressor TrpR [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948917, updated on 30-Jul-2025
Official Symbol
trpR
Official Full Name
DNA-binding transcriptional repressor TrpR
Primary source
ECOCYC:EG11029
Locus tag
b4393
See related
ASAP:ABE-0014408
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4385; rtrY
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Sequence:
NC_000913.3 (4632760..4633086)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene energy-dependent translational throttle protein EttA Neighboring gene soluble lytic murein transglycosylase Neighboring gene inosine/xanthosine triphosphatase Neighboring gene putative phosphatase Neighboring gene DNA-binding transcriptional dual regulator Rob

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Tandem binding in crystals of a trp repressor/operator half-site complex. Lawson CL, et al. Nature, 1993 Nov 11. PMID 8232559
  2. The solution structures of Escherichia coli trp repressor and trp aporepressor at an intermediate resolution. Arrowsmith C, et al. Eur J Biochem, 1991 Nov 15. PMID 1935980
  3. Fluorescence quenching studies of Trp repressor-operator interaction. Blicharska Z, et al. J Protein Chem, 1999 Nov. PMID 10839618
  4. Mutational analysis of the NH2-terminal arms of the trp repressor indicates a multifunctional domain. Mackintosh SG, et al. Mol Microbiol, 1998 Mar. PMID 9570398
  5. Purification and characterization of trp aporepressor. Joachimiak A, et al. Proc Natl Acad Sci U S A, 1983 Feb. PMID 6338493, Free PMC Article

See all (69) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. An asymmetric structure of bacterial TrpRS supports the half-of-the-sites catalytic mechanism and facilitates antimicrobial screening.
    Title: An asymmetric structure of bacterial TrpRS supports the half-of-the-sites catalytic mechanism and facilitates antimicrobial screening.
  2. Meta-Tyrosine Induces Cytotoxic Misregulation of Metabolism in Escherichia coli.
    Title: Meta-Tyrosine Induces Cytotoxic Misregulation of Metabolism in Escherichia coli.
  3. Multiple helical conformations of the helix-turn-helix region have been revealed by Nuclear Overhauser effect -restrained molecular dynamics simulations of tryptophan aporepressor, TrpR.
    Title: Multiple helical conformations of the helix-turn-helix region revealed by NOE-restrained MD simulations of tryptophan aporepressor, TrpR.
  4. Internal dynamics of the tryptophan repressor (TrpR) and two functionally distinct TrpR variants, L75F-TrpR and A77V-TrpR, in their l-Trp-bound forms.
    Title: Internal dynamics of the tryptophan repressor (TrpR) and two functionally distinct TrpR variants, L75F-TrpR and A77V-TrpR, in their l-Trp-bound forms.
  5. N-terminus verified by Edman degradation on mature peptide
    Title: Nucleotide sequence and expression of Escherichia coli trpR, the structural gene for the trp aporepressor.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
DNA-binding transcriptional repressor TrpR

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4632760..4633086
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418810.1 DNA-binding transcriptional repressor TrpR

    See identical proteins and their annotated locations for NP_418810.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A2Y0NE33, A0AB38EZI1
    Conserved Domains (1) summary
    COG2973
    Location:6 → 108
    TrpR; Trp operon repressor [Transcription]
Nucleotide Protein
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