U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

nadR DNA-binding transcriptional repressor/NMN adenylyltransferase NadR [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948911, updated on 25-Jun-2025
Official Symbol
nadR
Official Full Name
DNA-binding transcriptional repressor/NMN adenylyltransferase NadR
Primary source
ECOCYC:EG11335
Locus tag
b4390
See related
ASAP:ABE-0014397
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4382; nadI
Summary
The multifunctional protein "NAD regulator," NadR, has enzymatic as well as regulatory activity in the NAD biosynthetic pathway. [More information is available at EcoCyc: EG11335].
NEW
Try the new Gene table
Try the new Transcript table
Sequence:
NC_000913.3 (4627315..4628547)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene phosphoserine phosphatase Neighboring gene DNA recombination protein Neighboring gene energy-dependent translational throttle protein EttA Neighboring gene soluble lytic murein transglycosylase

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Evolution of the NadR regulon in Enterobacteriaceae. Gerasimova AV, et al. J Bioinform Comput Biol, 2005 Aug. PMID 16078372
  2. Ribosylnicotinamide kinase domain of NadR protein: identification and implications in NAD biosynthesis. Kurnasov OV, et al. J Bacteriol, 2002 Dec. PMID 12446641, Free PMC Article
  3. Recognition of a gene involved in the regulation of nicotinamide adenine dinucleotide biosynthesis. Tritz GJ, et al. J Bacteriol, 1973 Apr. PMID 4349027, Free PMC Article
  4. Pyridine nucleotide cycle of Salmonella typhimurium: isolation and characterization of pncA, pncB, and pncC mutants and utilization of exogenous nicotinamide adenine dinucleotide. Foster JW, et al. J Bacteriol, 1979 Mar. PMID 220211, Free PMC Article
  5. Pyridine nucleotide cycle of Salmonella typhimurium: in vitro demonstration of nicotinamide mononucleotide deamidase and characterization of pnuA mutants defective in nicotinamide mononucleotide transport. Kinney DM, et al. J Bacteriol, 1979 Nov. PMID 387742, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables nicotinamide-nucleotide adenylyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nicotinamide-nucleotide adenylyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ribosylnicotinamide kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in NAD+ biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to metal ion IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within protein homotetramerization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to alkaline pH IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of adenylyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of catalytic complex IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
DNA-binding transcriptional repressor/NMN adenylyltransferase NadR
NP_418807.4

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4627315..4628547
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418807.4 DNA-binding transcriptional repressor/NMN adenylyltransferase NadR [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418807.4

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A7A6VRZ5
    Conserved Domains (1) summary
    PRK08099
    Location:13 → 409
    PRK08099; multifunctional transcriptional regulator/nicotinamide-nucleotide adenylyltransferase/ribosylnicotinamide kinase NadR
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.