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slt soluble lytic murein transglycosylase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948908, updated on 25-Jun-2025
Official Symbol
slt
Official Full Name
soluble lytic murein transglycosylase
Primary source
ECOCYC:EG10950
Locus tag
b4392
See related
ASAP:ABE-0014404
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4384; sltY
Summary
Slt cleaves the glycosidic bonds between the N-acetylmuramic acid and N-acetylglucosamine residues in murein. [More information is available at EcoGene: EG10950]. Slt70 is involved in growth and recycling of peptidoglycan by catalyzing the lysis of the -1,4 glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine, producing 1,6-anhydromuropeptides at an optimal pH of 4.5 with a Km of 200 mg/L . [More information is available at EcoCyc: EG10950].
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Sequence:
NC_000913.3 (4630733..4632670)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional repressor/NMN adenylyltransferase NadR Neighboring gene energy-dependent translational throttle protein EttA Neighboring gene DNA-binding transcriptional repressor TrpR Neighboring gene inosine/xanthosine triphosphatase

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Beta-lactam antibiotics induce a lethal malfunctioning of the bacterial cell wall synthesis machinery. Cho H, et al. Cell, 2014 Dec 4. PMID 25480295, Free PMC Article
  2. Exoenzymatic activity of transglycosylase isolated from Escherichia coli. Beachey EH, et al. Eur J Biochem, 1981 May 15. PMID 7018908
  3. Doughnut-shaped structure of a bacterial muramidase revealed by X-ray crystallography. Thunnissen AM, et al. Nature, 1994 Feb 24. PMID 8107871
  4. Crystallization of the soluble lytic transglycosylase from Escherichia coli K12. Rozeboom HJ, et al. J Mol Biol, 1990 Apr 20. PMID 2184239
  5. Control of the activity of the soluble lytic transglycosylase by the stringent response in Escherichia coli. Betzner AS, et al. FEMS Microbiol Lett, 1990 Jan 15. PMID 1970319

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on mature peptide
    Title: Murein-metabolizing enzymes from Escherichia coli: sequence analysis and controlled overexpression of the slt gene, which encodes the soluble lytic transglycosylase.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables lytic endotransglycosylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables peptidoglycan lytic transglycosylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables peptidoglycan lytic transglycosylase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within peptidoglycan catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within peptidoglycan catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in outer membrane-bounded periplasmic space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in peptidoglycan-based cell wall IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
soluble lytic murein transglycosylase

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4630733..4632670
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418809.4 soluble lytic murein transglycosylase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418809.4

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376ZMZ2, A0A7A2XMD5, A0A8I0CGC3, A0A8T5YEM3
    Conserved Domains (1) summary
    PRK11619
    Location:1 → 645
    PRK11619; lytic murein transglycosylase; Provisional
Nucleotide Protein
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