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tolQ Tol-Pal system protein TolQ [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948900, updated on 26-Nov-2024

Summary

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Official Symbol
tolQ
Official Full Name
Tol-Pal system protein TolQ
Primary source
ECOCYC:EG11010
Locus tag
b0737
See related
ASAP:ABE-0002511
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0726; fii; tolP
Summary
TolQ is one of three (along with TolA and TolR) inner membrane protein members of the YbgC-YbgF-TolQ-R-A-B-Pal Cell Envelope Complex, also known as the Tol-Pal system. [More information is available at EcoCyc: EG11010].
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Genomic context

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Sequence:
NC_000913.3 (775153..775845)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene cytochrome bd-I accessory subunit CydX Neighboring gene PF09600 family protein YbgE Neighboring gene esterase/thioesterase Neighboring gene Tol-Pal system protein TolR Neighboring gene Tol-Pal system protein TolA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Role of TolR N-terminal, central, and C-terminal domains in dimerization and interaction with TolA and tolQ. Journet L, et al. J Bacteriol, 1999 Aug. PMID 10419942, Free PMC Article
  2. Membrane topology and mutational analysis of the TolQ protein of Escherichia coli required for the uptake of macromolecules and cell envelope integrity. Vianney A, et al. J Bacteriol, 1994 Feb. PMID 8300535, Free PMC Article
  3. Localization and assembly into the Escherichia coli envelope of a protein required for entry of colicin A. Bourdineaud JP, et al. J Bacteriol, 1989 May. PMID 2651401, Free PMC Article
  4. Direct interaction between fd phage pilot protein pIII and the TolQ-TolR proton-dependent motor provides new insights into the import of filamentous phages. Pellegri C, et al. J Biol Chem, 2023 Aug. PMID 37451481, Free PMC Article
  5. Membrane topology of the Escherichia coli TolR protein required for cell envelope integrity. Muller MM, et al. J Bacteriol, 1993 Sep. PMID 8376353, Free PMC Article

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Direct interaction between fd phage pilot protein pIII and the TolQ-TolR proton-dependent motor provides new insights into the import of filamentous phages.
    Title: Direct interaction between fd phage pilot protein pIII and the TolQ-TolR proton-dependent motor provides new insights into the import of filamentous phages.
  2. Authors suggest a model wherein the overexpression of TolQ sequesters FtsN, depleting this essential protein from the divisome during Gram-negative cell division.
    Title: Overexpression of the Escherichia coli TolQ protein leads to a null-FtsN-like division phenotype.
  3. N-terminus verified by Edman degradation on complete protein
    Title: Membrane topology and mutational analysis of the TolQ protein of Escherichia coli required for the uptake of macromolecules and cell envelope integrity.
  4. Data show that movements of the TolR C-terminal domain depend on TolQR ionizable key residues and regulate activity of the Tol complex.
    Title: Movements of the TolR C-terminal domain depend on TolQR ionizable key residues and regulate activity of the Tol complex.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in bacteriocin transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within bacteriocin transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell division EXP
Inferred from Experiment
more info
 PubMed 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in cell division NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within cell septum assembly EXP
Inferred from Experiment
more info
 PubMed 
involved_in protein import IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein import IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of membrane invagination NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cell division site IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell envelope IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Tol-Pal system protein TolQ

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    775153..775845
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415265.1 Tol-Pal system protein TolQ [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415265.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376TIM9
    Conserved Domains (1) summary
    PRK10801
    Location:4 → 230
    PRK10801; Tol-Pal system protein TolQ
Nucleotide Protein
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