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yjjG pyrimidine 5'-nucleotidase YjjG [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948899, updated on 26-Jun-2024

Summary

Gene symbol
yjjG
Gene description
pyrimidine 5'-nucleotidase YjjG
Primary source
ASAP:ABE-0014344
Locus tag
b4374
See related
ECOCYC:EG12115
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4365
Summary
Efficient in vitro substrates include: dUMP, UMP, and dTMP; phosphoramidase: in vitro activities demonstrated by Kuznetsova et al. [More information is available at EcoGene: EG12115]. YjjG is a monophosphatase whose activity is essential for thymine salvage in a thyA (|FRAME: [More information is available at EcoCyc: EG12115].
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Genomic context

Sequence:
NC_000913.3 (4608646..4609323)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene 16S rRNA m(2)G1207 methyltransferase Neighboring gene DNA polymerase III subunit psi Neighboring gene protein N-acetyltransferase RimI Neighboring gene peptide chain release factor RF3 Neighboring gene periplasmic chaperone OsmY

Bibliography

General gene information

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 5'-nucleotidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables 5'-nucleotidase activity IEA
Inferred from Electronic Annotation
more info
 
enables XMP 5'-nucleosidase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables manganese ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables thymidylate 5'-phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in pyrimidine nucleobase salvage IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within response to xenobiotic stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in thymine metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
pyrimidine 5'-nucleotidase YjjG
NP_418791.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4608646..4609323
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418791.1 pyrimidine 5'-nucleotidase YjjG [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418791.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S7CVR0
    Conserved Domains (1) summary
    PRK09449
    Location:1224
    PRK09449; dUMP phosphatase; Provisional