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osmY periplasmic chaperone OsmY [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948895, updated on 10-Oct-2024

Summary

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Official Symbol
osmY
Official Full Name
periplasmic chaperone OsmY
Primary source
ECOCYC:EG11391
Locus tag
b4376
See related
ASAP:ABE-0014348
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
csi-5; ECK4367
Summary
RpoS regulon. [More information is available at EcoGene: EG11391]. Mutation of osmY resulted in increases sensitivity to hyperosmotic stress . [More information is available at EcoCyc: EG11391].
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Genomic context

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Sequence:
NC_000913.3 (4611396..4612001)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene pyrimidine 5'-nucleotidase YjjG Neighboring gene peptide chain release factor RF3 Neighboring gene DUF1328 domain-containing protein YtjA Neighboring gene putative patatin-like phospholipase YjjU Neighboring gene putative metal-dependent hydrolase YjjV

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Chaperone OsmY facilitates the biogenesis of a major family of autotransporters. Yan Z, et al. Mol Microbiol, 2019 Nov. PMID 31369167, Free PMC Article
  2. Osmo-regulation of bacterial transcription via poised RNA polymerase. Lee SJ, et al. Mol Cell, 2004 Apr 23. PMID 15099515
  3. Cecropins induce the hyperosmotic stress response in Escherichia coli. Oh JT, et al. Biochim Biophys Acta, 1998 Dec 9. PMID 9858741
  4. Molecular characterization of the promoter of osmY, an rpoS-dependent gene. Yim HH, et al. J Bacteriol, 1994 Jan. PMID 8282684, Free PMC Article
  5. Complex transcriptional control of the sigma s-dependent stationary-phase-induced and osmotically regulated osmY (csi-5) gene suggests novel roles for Lrp, cyclic AMP (cAMP) receptor protein-cAMP complex, and integration host factor in the stationary-phase response of Escherichia coli. Lange R, et al. J Bacteriol, 1993 Dec. PMID 8253679, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Structure and Function of the Bacterial Osmotically Inducible Protein Y.
    Title: The Structure and Function of the Bacterial Osmotically Inducible Protein Y.
  2. The results indicate that OsmY is involved in the biogenesis of a major subset of autotransporters, a group of proteins that play key roles in bacterial pathogenesis.
    Title: Chaperone OsmY facilitates the biogenesis of a major family of autotransporters.
  3. A C-terminal tail unique among sigma factors is shown to be required for in vivo recruitment of RNA polymerase to the promoter region prior to osmotic shock.
    Title: Poising of Escherichia coli RNA polymerase and its release from the sigma 38 C-terminal tail for osmY transcription.
  4. N-terminus verified by Edman degradation on mature peptide
    Title: Protein identification with N and C-terminal sequence tags in proteome projects.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in chaperone-mediated protein folding IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in hyperosmotic response IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to osmotic stress IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in outer membrane-bounded periplasmic space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in outer membrane-bounded periplasmic space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in periplasmic space IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
periplasmic chaperone OsmY

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4611396..4612001
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418793.1 periplasmic chaperone OsmY [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418793.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8T5ZI25, A0AAQ2LP50
    Conserved Domains (1) summary
    PRK10568
    Location:3 → 201
    PRK10568; molecular chaperone OsmY
Nucleotide Protein
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