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ampD 1,6-anhydro-N-acetylmuramoyl-L-alanine amidase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948877, updated on 17-Jul-2025
Official Symbol
ampD
Official Full Name
1,6-anhydro-N-acetylmuramoyl-L-alanine amidase
Primary source
ECOCYC:EG10041
Locus tag
b0110
See related
ASAP:ABE-0000380
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0109
Summary
ampD is a member of the ampDE operon. [More information is available at EcoCyc: EG10041].
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Sequence:
NC_000913.3 (118733..119284)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene prepilin-type N-terminal cleavage/methylation domain-containing protein PpdD Neighboring gene quinolinate phosphoribosyltransferase (decarboxylating) Neighboring gene protein AmpE Neighboring gene aromatic amino acid:H(+) symporter AroP Neighboring gene DNA-binding transcriptional dual regulator PdhR

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Bacterial AmpD at the crossroads of peptidoglycan recycling and manifestation of antibiotic resistance. Lee M, et al. J Am Chem Soc, 2009 Jul 1. PMID 19496566, Free PMC Article
  2. Total synthesis of N-acetylglucosamine-1,6-anhydro-N-acetylmuramylpentapeptide and evaluation of its turnover by AmpD from Escherichia coli. Hesek D, et al. J Am Chem Soc, 2009 Apr 15. PMID 19309146, Free PMC Article
  3. Stress-induced beta-lactam antibiotic resistance mutation and sequences of stationary-phase mutations in the Escherichia coli chromosome. Petrosino JF, et al. J Bacteriol, 2009 Oct. PMID 19648247, Free PMC Article
  4. The negative regulator of beta-lactamase induction AmpD is a N-acetyl-anhydromuramyl-L-alanine amidase. Höltje JV, et al. FEMS Microbiol Lett, 1994 Sep 15. PMID 7958768
  5. Factors influencing gene expression and resistance for Gram-negative organisms expressing plasmid-encoded ampC genes of Enterobacter origin. Reisbig MD, et al. J Antimicrob Chemother, 2003 May. PMID 12697654

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables N-acetyl-anhydromuramoyl-L-alanine amidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables N-acetylmuramoyl-L-alanine amidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in peptidoglycan catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidoglycan turnover IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidoglycan turnover IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Preferred Names
1,6-anhydro-N-acetylmuramoyl-L-alanine amidase
NP_414652.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    118733..119284
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414652.1 1,6-anhydro-N-acetylmuramoyl-L-alanine amidase

    See identical proteins and their annotated locations for NP_414652.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q14F42
    Conserved Domains (1) summary
    PRK11789
    Location:1 → 183
    PRK11789; 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD
Nucleotide Protein
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