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ampD 1,6-anhydro-N-acetylmuramoyl-L-alanine amidase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948877, updated on 27-Nov-2023

Summary

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Gene symbol
ampD
Gene description
1,6-anhydro-N-acetylmuramoyl-L-alanine amidase
Primary source
ASAP:ABE-0000380
Locus tag
b0110
See related
ECOCYC:EG10041
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0109
Summary
ampD is a member of the ampDE operon. [More information is available at EcoCyc: EG10041].
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Genomic context

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Sequence:
NC_000913.3 (118733..119284)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene prepilin-type N-terminal cleavage/methylation domain-containing protein PpdD Neighboring gene quinolinate phosphoribosyltransferase (decarboxylating) Neighboring gene protein AmpE Neighboring gene aromatic amino acid:H(+) symporter AroP Neighboring gene DNA-binding transcriptional dual regulator PdhR

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Stress-induced beta-lactam antibiotic resistance mutation and sequences of stationary-phase mutations in the Escherichia coli chromosome. Petrosino JF, et al. J Bacteriol, 2009 Oct. PMID 19648247, Free PMC Article
  2. Bacterial AmpD at the crossroads of peptidoglycan recycling and manifestation of antibiotic resistance. Lee M, et al. J Am Chem Soc, 2009 Jul 1. PMID 19496566, Free PMC Article
  3. Total synthesis of N-acetylglucosamine-1,6-anhydro-N-acetylmuramylpentapeptide and evaluation of its turnover by AmpD from Escherichia coli. Hesek D, et al. J Am Chem Soc, 2009 Apr 15. PMID 19309146, Free PMC Article
  4. Factors influencing gene expression and resistance for Gram-negative organisms expressing plasmid-encoded ampC genes of Enterobacter origin. Reisbig MD, et al. J Antimicrob Chemother, 2003 May. PMID 12697654
  5. The negative regulator of beta-lactamase induction AmpD is a N-acetyl-anhydromuramyl-L-alanine amidase. Höltje JV, et al. FEMS Microbiol Lett, 1994 Sep 15. PMID 7958768

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables N-acetyl-anhydromuramoyl-L-alanine amidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables N-acetylmuramoyl-L-alanine amidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables N-acetylmuramoyl-L-alanine amidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell wall organization IEA
Inferred from Electronic Annotation
more info
  
involved_in peptidoglycan catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidoglycan catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in peptidoglycan turnover IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidoglycan turnover IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
1,6-anhydro-N-acetylmuramoyl-L-alanine amidase
NP_414652.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    118733..119284
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414652.1 1,6-anhydro-N-acetylmuramoyl-L-alanine amidase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414652.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    Q14F42
    Conserved Domains (1) summary
    PRK11789
    Location:1 → 183
    PRK11789; 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD
Nucleotide Protein
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