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arcA DNA-binding transcriptional dual regulator ArcA [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948874, updated on 3-Dec-2024
Official Symbol
arcA
Official Full Name
DNA-binding transcriptional dual regulator ArcA
Primary source
ECOCYC:EG10061
Locus tag
b4401
See related
ASAP:ABE-0014434
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
cpxC; dye; ECK4393; fexA; msp; seg; sfrA
Summary
This is a dual transcriptional regulator of aerobic respiration control. [More information is available at EcoCyc: EG10061].
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Sequence:
NC_000913.3 (4639590..4640306, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional regulator CreB Neighboring gene sensory histidine kinase CreC Neighboring gene putative inner membrane protein CreD Neighboring gene uncharacterized protein YjjY Neighboring gene protein YtjE

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Identification of the dye gene product, mutational loss of which alters envelope protein composition and also affects sex factor F expression in Escherichia coli K-12. Buxton RS, et al. Mol Gen Genet, 1984. PMID 6328216
  2. Structural analysis and solution studies of the activated regulatory domain of the response regulator ArcA: a symmetric dimer mediated by the alpha4-beta5-alpha5 face. Toro-Roman A, et al. J Mol Biol, 2005 May 27. PMID 15876365, Free PMC Article
  3. ArcA redox mutants as a source of reduced bioproducts. Pettinari MJ, et al. J Mol Microbiol Biotechnol, 2008. PMID 18349549
  4. Cooperative Function of TraJ and ArcA in Regulating the F Plasmid tra Operon. Lu J, et al. J Bacteriol, 2019 Jan 1. PMID 30322855, Free PMC Article
  5. ArcA overexpression induces fermentation and results in enhanced growth rates of E. coli. Basan M, et al. Sci Rep, 2017 Sep 19. PMID 28928483, Free PMC Article

See all (124) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Role of ArcA in the regulation of antibiotic sensitivity in avian pathogenic Escherichia coli.
    Title: Role of ArcA in the regulation of antibiotic sensitivity in avian pathogenic Escherichia coli.
  2. Theoretical study of ArcB and its dimerization, interaction with anaerobic metabolites, and activation of ArcA.
    Title: Theoretical study of ArcB and its dimerization, interaction with anaerobic metabolites, and activation of ArcA.
  3. The results suggest that deletion of arcA, iclR, and tdcC could efficiently increase l-threonine production in E. coli.
    Title: Deletion of arcA, iclR, and tdcC in Escherichia coli to improve l-threonine production.
  4. These data reveal the cooperativity of TraJ and ArcA during F plasmid PY promoter activation and provide insights into the regulatory circuit controlling F-family plasmid-mediated bacterial conjugation.
    Title: Cooperative Function of TraJ and ArcA in Regulating the F Plasmid tra Operon.
  5. Study reports the in-situ structure of the E. coli AcrAB-TolC multidrug efflux pump obtained by electron cryo-tomography. The fully assembled efflux pump is observed in a closed state under conditions of antibiotic challenge and in an open state in the presence of AcrB inhibitor. Also study observed intermediate AcrAB complexes without TolC and discover that AcrA contacts the peptidoglycan layer of the periplasm.
    Title: In situ structure and assembly of the multidrug efflux pump AcrAB-TolC.
  6. increased lag phases of ArcA overexpression strains, respiratory energy metabolism may be related to a general preparatory response, observed for decreasing growth rates, but with limited advantages for maximizing steady-state growth rate.
    Title: ArcA overexpression induces fermentation and results in enhanced growth rates of E. coli.
  7. The authors report the near-atomic resolution cryoEM structures of the Escherichia coli AcrAB-TolC multidrug efflux pump in resting and drug transport states, revealing a quaternary structural switch that allosterically couples and synchronizes initial ligand binding with channel opening.
    Title: An allosteric transport mechanism for the AcrAB-TolC multidrug efflux pump.
  8. The combined results indicate that ArcA controls metabolism, chemotaxis, and motility contributing to the pathogenicity of Avian pathogenic Escherichia coli
    Title: ArcA Controls Metabolism, Chemotaxis, and Motility Contributing to the Pathogenicity of Avian Pathogenic Escherichia coli.
  9. We propose that this plasticity in ArcA binding site architecture provides both an efficient means of encoding binding sites for ArcA, sigma(70)-RNAP and perhaps other transcription factors
    Title: The bacterial response regulator ArcA uses a diverse binding site architecture to regulate carbon oxidation globally.
  10. Interactions between TolC and AcrAB are highly dynamic and only a small fraction of TolC is utilized to support efflux activities.
    Title: On the role of TolC in multidrug efflux: the function and assembly of AcrAB-TolC tolerate significant depletion of intracellular TolC protein.
Submit: New GeneRIF Correction See all GeneRIFs (27)

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables DNA-binding transcription repressor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables phosphorelay response regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphorelay response regulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription cis-regulatory region binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription cis-regulatory region binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
acts_upstream_of_or_within phosphorelay signal transduction system IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phosphorelay signal transduction system IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-DNA complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein-DNA complex IPI
Inferred from Physical Interaction
more info
 PubMed 
Preferred Names
DNA-binding transcriptional dual regulator ArcA

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4639590..4640306 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418818.1 DNA-binding transcriptional dual regulator ArcA [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418818.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5B9AAK3
    Conserved Domains (1) summary
    PRK11173
    Location:1 → 237
    PRK11173; two-component response regulator; Provisional
Nucleotide Protein
Heading Accession and Version

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