Format

Send to:

Choose Destination

mdtM multidrug efflux pump/bile salt:H(+) antiporter/Na(+):H(+) antiporter/K(+):H(+) antiporter [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948861, updated on 10-Nov-2018

Summary

Gene symbol
mdtM
Gene description
multidrug efflux pump/bile salt:H(+) antiporter/Na(+):H(+) antiporter/K(+):H(+) antiporter
Primary source
EcoGene:EG12576
Locus tag
b4337
See related
ASAP:ABE-0014221; ECOCYC:EG12576
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4328; yjiO
Summary
Major Facilitator Superfamily (MFS). [More information is available at EcoGene: EG12576]. The YjiO protein is, based on sequence similarity and hydropathy analysis, a member of the major facilitator superfamily (MFS) . [More information is available at EcoCyc: EG12576].

Genomic context

Sequence:
NC_000913.3 (4567287..4568519, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative dehydratase subunit Neighboring gene DUF445 domain-containing protein YjiN Neighboring gene pseudo Neighboring gene fused putative DNA-binding transcriptional regulator/putative aminotransferase YjiR

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

General gene information

Gene Ontology Provided by GO

Function Evidence Code Pubs
drug transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
drug transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
drug:proton antiporter activity IDA
Inferred from Direct Assay
more info
PubMed 
potassium:proton antiporter activity IDA
Inferred from Direct Assay
more info
PubMed 
sodium:proton antiporter activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
drug transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
drug transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cellular pH IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to antibiotic IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
multidrug efflux pump/bile salt:H(+) antiporter/Na(+):H(+) antiporter/K(+):H(+) antiporter

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4567287..4568519 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418757.1 multidrug efflux pump/bile salt:H(+) antiporter/Na(+):H(+) antiporter/K(+):H(+) antiporter [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418757.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P39386
    Conserved Domains (1) summary
    PRK15403
    Location:1410
    PRK15403; multidrug efflux system protein MdtM; Provisional
Support Center