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uxuR DNA-binding transcriptional repressor UxuR [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948849, updated on 30-Jul-2025
Official Symbol
uxuR
Official Full Name
DNA-binding transcriptional repressor UxuR
Primary source
ECOCYC:EG20249
Locus tag
b4324
See related
ASAP:ABE-0014179
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4315
Summary
UxuR regulon. [More information is available at EcoGene: EG20249]. UxuR is a protein that belongs to the GntR family and participates as a regulator in controlling several genes involved in carbon uptake. [More information is available at EcoCyc: EG20249].
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Sequence:
NC_000913.3 (4554576..4555349)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene D-mannonate dehydratase Neighboring gene D-mannonate oxidoreductase Neighboring gene DUF2686 domain-containing protein YjiC Neighboring gene protein YtiC Neighboring gene protein YtiD

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. UxuR is essential for rapid growth with D-glucuronate as the primary source of carbon and energy.
    Title: Control of hexuronate metabolism in Escherichia coli by the two interdependent regulators, ExuR and UxuR: derepression by heterodimer formation.
  2. a module of sugar acid catabolism whose physiological role is for growth on fructuronate
    Title: GntP is the Escherichia coli Fructuronic acid transporter and belongs to the UxuR regulon.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA-templated transcription IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
DNA-binding transcriptional repressor UxuR

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4554576..4555349
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418744.1 DNA-binding transcriptional repressor UxuR

    See identical proteins and their annotated locations for NP_418744.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A6N8NGI1
    Conserved Domains (1) summary
    PRK10225
    Location:1 → 257
    PRK10225; Uxu operon transcriptional regulator
Nucleotide Protein
Heading Accession and Version

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