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fimH type 1 fimbriae D-mannose specific adhesin [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948847, updated on 17-Jul-2021

Summary

Gene symbol
fimH
Gene description
type 1 fimbriae D-mannose specific adhesin
Primary source
ASAP:ABE-0014157
Locus tag
b4320
See related
ECOCYC:EG10315
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4311; pilE
Summary
Mutants of FimH have been isolated that auto-aggregate. [More information is available at EcoGene: EG10315]. Type 1, or mannose-sensitive, fimbriae in Escherichia coli mediate binding to receptor structures allowing the bacteria to colonize various host tissues. [More information is available at EcoCyc: EG10315].
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Genomic context

Sequence:
NC_000913.3 (4548808..4549710)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene type 1 fimbriae minor subunit FimF Neighboring gene type 1 fimbriae minor subunit FimG Neighboring gene fructuronate transporter Neighboring gene D-mannonate dehydratase

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables mannose binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell adhesion involved in single-species biofilm formation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in pilus organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in host cell membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in pilus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in pilus IEA
Inferred from Electronic Annotation
more info
 
located_in pilus IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
type 1 fimbriae D-mannose specific adhesin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4548808..4549710
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418740.1 type 1 fimbriae D-mannose specific adhesin [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418740.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P08191
    Conserved Domains (2) summary
    pfam09160
    Location:25168
    FimH_man-bind; FimH, mannose binding
    cl01416
    Location:182300
    Fimbrial; Fimbrial protein
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