U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

fimH [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948847, updated on 11-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
fimH
Primary source
ECOCYC:EG10315
Locus tag
b4320
See related
ASAP:ABE-0014157
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4311; pilE
Summary
Mutants of FimH have been isolated that auto-aggregate. [More information is available at EcoGene: EG10315]. Type 1, or mannose-sensitive, fimbriae in Escherichia coli mediate binding to receptor structures allowing the bacteria to colonize various host tissues. [More information is available at EcoCyc: EG10315].
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Sequence:
NC_000913.3 (4548808..4549710)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene type 1 fimbriae minor subunit FimF Neighboring gene type 1 fimbriae minor subunit FimG Neighboring gene fructuronate transporter Neighboring gene D-mannonate dehydratase

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Recombinant FimH Adhesin Demonstrates How the Allosteric Catch Bond Mechanism Can Support Fast and Strong Bacterial Attachment in the Absence of Shear. Thomas WE, et al. J Mol Biol, 2022 Sep 15. PMID 35697293, Free PMC Article
  2. Structural and functional characterization of the FimH adhesin of uropathogenic Escherichia coli and its novel applications. Foroogh N, et al. Microb Pathog, 2021 Dec. PMID 34780972
  3. Escherichia coli FimH adhesins act synergistically with PapGII adhesins for enhancing establishment and maintenance of kidney infection. Tseng CC, et al. J Microbiol Immunol Infect, 2022 Feb. PMID 33023843
  4. Conformational stability of the bacterial adhesin, FimH, with an inactivating mutation. Liu J, et al. Proteins, 2021 Mar. PMID 32989832, Free PMC Article
  5. RMSD analysis of structures of the bacterial protein FimH identifies five conformations of its lectin domain. Magala P, et al. Proteins, 2020 Apr. PMID 31622514, Free PMC Article

See all (101) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Escherichia coli adhesion protein FimH exacerbates colitis via CD11b[+]CD103[-] dendritic cell activation.
    Title: Escherichia coli adhesion protein FimH exacerbates colitis via CD11b(+)CD103(-) dendritic cell activation.
  2. Escherichia coli adhesion portion FimH polarizes M2 macrophages to M1 macrophages in tumor microenvironment via toll-like receptor 4.
    Title: Escherichia coli adhesion portion FimH polarizes M2 macrophages to M1 macrophages in tumor microenvironment via toll-like receptor 4.
  3. Recombinant FimH Adhesin Demonstrates How the Allosteric Catch Bond Mechanism Can Support Fast and Strong Bacterial Attachment in the Absence of Shear.
    Title: Recombinant FimH Adhesin Demonstrates How the Allosteric Catch Bond Mechanism Can Support Fast and Strong Bacterial Attachment in the Absence of Shear.
  4. Escherichia coli FimH adhesins act synergistically with PapGII adhesins for enhancing establishment and maintenance of kidney infection.
    Title: Escherichia coli FimH adhesins act synergistically with PapGII adhesins for enhancing establishment and maintenance of kidney infection.
  5. Structural and functional characterization of the FimH adhesin of uropathogenic Escherichia coli and its novel applications.
    Title: Structural and functional characterization of the FimH adhesin of uropathogenic Escherichia coli and its novel applications.
  6. Conformational stability of the bacterial adhesin, FimH, with an inactivating mutation.
    Title: Conformational stability of the bacterial adhesin, FimH, with an inactivating mutation.
  7. RMSD analysis of structures of the bacterial protein FimH identifies five conformations of its lectin domain.
    Title: RMSD analysis of structures of the bacterial protein FimH identifies five conformations of its lectin domain.
  8. Conformational switch of the bacterial adhesin FimH in the absence of the regulatory domain.
    Title: Conformational switch of the bacterial adhesin FimH in the absence of the regulatory domain: Engineering a minimalistic allosteric system.
  9. Evolutionary fine-tuning of conformational ensembles in FimH during host-pathogen interactions.
    Title: Evolutionary fine-tuning of conformational ensembles in FimH during host-pathogen interactions.
  10. A mutant missing the type 1 pilus-associated adhesin FimH displayed somewhat reduced persistence within the gut.
    Title: Context-Dependent Requirements for FimH and Other Canonical Virulence Factors in Gut Colonization by Extraintestinal Pathogenic Escherichia coli.
Submit: New GeneRIF Correction See all GeneRIFs (35)

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables D-mannose binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell adhesion involved in single-species biofilm formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-substrate adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mechanosensory behavior IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in pilus organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in host cell membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in pilus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in pilus IEA
Inferred from Electronic Annotation
more info
  
located_in pilus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in pilus tip IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
type 1 fimbriae D-mannose specific adhesin

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4548808..4549710
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418740.1 type 1 fimbriae D-mannose specific adhesin [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418740.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0AAI9M1R2, Q9F5S0, Q9F5S1, Q9S496, Q9S497
    Conserved Domains (2) summary
    pfam09160
    Location:25 → 168
    FimH_man-bind; FimH, mannose binding
    cl01416
    Location:182 → 300
    Fimbrial; Fimbrial protein
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.