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fadI 3-ketoacyl-CoA thiolase FadI [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948823, updated on 26-Jun-2024

Summary

Gene symbol
fadI
Gene description
3-ketoacyl-CoA thiolase FadI
Primary source
ASAP:ABE-0007725
Locus tag
b2342
See related
ECOCYC:G7213
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2336; yfcY
Summary
Also known as beta-oxidation complex II. [More information is available at EcoGene: EG14128]. During anaerobic beta-oxidation of fatty acids FadI, FadJ, and FadK serve functions parallel to those of FadA, FadB, and FadD in the aerobic pathway . [More information is available at EcoCyc: G7213].
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Genomic context

Sequence:
NC_000913.3 (2459159..2460469, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative fimbrial protein YfcV Neighboring gene phosphohistidine phosphatase SixA Neighboring gene 3-hydroxyacyl-CoA dehydrogenase FadJ Neighboring gene DUF406 domain-containing protein YfcZ Neighboring gene long-chain fatty acid outer membrane channel/bacteriophage T2 receptor

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by EcoCyc

Process Evidence Code Pubs
involved_in fatty acid beta-oxidation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in fatty acid beta-oxidation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within fatty acid beta-oxidation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within fatty acid beta-oxidation, unsaturated, even number IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in small molecule metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
part_of fatty acid beta-oxidation multienzyme complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
3-ketoacyl-CoA thiolase FadI
NP_416844.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2459159..2460469 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416844.1 3-ketoacyl-CoA thiolase FadI [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416844.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2H4TX56
    Conserved Domains (1) summary
    PRK08963
    Location:9436
    fadI; 3-ketoacyl-CoA thiolase; Reviewed