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PIGB phosphatidylinositol glycan anchor biosynthesis class B [ Homo sapiens (human) ]

Gene ID: 9488, updated on 12-Oct-2019

Summary

Official Symbol
PIGBprovided by HGNC
Official Full Name
phosphatidylinositol glycan anchor biosynthesis class Bprovided by HGNC
Primary source
HGNC:HGNC:8959
See related
Ensembl:ENSG00000069943 MIM:604122
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PIG-B; EIEE80; GPI-MT-III
Summary
This gene encodes a transmembrane protein that is located in the endoplasmic reticulum and is involved in GPI-anchor biosynthesis. The glycosylphosphatidylinositol (GPI) anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This gene is thought to encode a member of a family of dolichol-phosphate-mannose (Dol-P-Man) dependent mannosyltransferases. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 8.6), prostate (RPKM 5.8) and 25 other tissues See more
Orthologs

Genomic context

See PIGB in Genome Data Viewer
Location:
15q21.3
Exon count:
15
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (55318939..55355648)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (55611133..55647906)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene ribosomal L24 domain containing 1 Neighboring gene RAB27A, member RAS oncogene family Neighboring gene Sharpr-MPRA regulatory region 6285 Neighboring gene PIGB opposite strand 1 Neighboring gene DNAAF4-CCPG1 readthrough (NMD candidate) Neighboring gene cell cycle progression 1 Neighboring gene microRNA 628 Neighboring gene chromosome 15 open reading frame 65 Neighboring gene dynein axonemal assembly factor 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC21236

Gene Ontology Provided by GOA

Function Evidence Code Pubs
glycolipid mannosyltransferase activity TAS
Traceable Author Statement
more info
 
mannosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mannosyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
GPI anchor biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GPI anchor biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
mannosylation IDA
Inferred from Direct Assay
more info
PubMed 
preassembly of GPI anchor in ER membrane TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
GPI mannosyltransferase 3
Names
GPI mannosyltransferase III
dol-P-Man dependent GPI mannosyltransferase
phosphatidylinositol glycan, class B
phosphatidylinositol-glycan biosynthesis class B protein
NP_004846.4
XP_005254852.1
XP_011520537.1
XP_011520538.1
XP_011520539.1
XP_016878219.1
XP_016878220.1
XP_016878221.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004855.5NP_004846.4  GPI mannosyltransferase 3

    See identical proteins and their annotated locations for NP_004846.4

    Status: REVIEWED

    Source sequence(s)
    AC018926, AK223330, DA598474
    Consensus CDS
    CCDS61641.1
    UniProtKB/Swiss-Prot
    Q92521
    Related
    ENSP00000164305.5, ENST00000164305.10
    Conserved Domains (1) summary
    pfam03901
    Location:62449
    Glyco_transf_22; Alg9-like mannosyltransferase family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    55318939..55355648
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011522235.3XP_011520537.1  GPI mannosyltransferase 3 isoform X1

    Conserved Domains (1) summary
    pfam03901
    Location:62434
    Glyco_transf_22; Alg9-like mannosyltransferase family
  2. XM_011522236.3XP_011520538.1  GPI mannosyltransferase 3 isoform X2

    Conserved Domains (1) summary
    pfam03901
    Location:62414
    Glyco_transf_22; Alg9-like mannosyltransferase family
  3. XM_005254795.5XP_005254852.1  GPI mannosyltransferase 3 isoform X4

    Conserved Domains (1) summary
    cl21590
    Location:1288
    PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase
  4. XM_017022732.2XP_016878221.1  GPI mannosyltransferase 3 isoform X5

  5. XM_011522237.2XP_011520539.1  GPI mannosyltransferase 3 isoform X3

    Conserved Domains (1) summary
    cl21590
    Location:7316
    PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase
  6. XM_017022730.1XP_016878219.1  GPI mannosyltransferase 3 isoform X3

    Conserved Domains (1) summary
    cl21590
    Location:7316
    PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase
  7. XM_017022731.1XP_016878220.1  GPI mannosyltransferase 3 isoform X3

    Conserved Domains (1) summary
    cl21590
    Location:7316
    PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

RNA

  1. XR_931950.3 RNA Sequence

  2. XR_001751423.2 RNA Sequence

  3. XR_001751422.2 RNA Sequence

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