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appY DNA-binding transcriptional activator AppY [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948797, updated on 17-Dec-2024
Official Symbol
appY
Official Full Name
DNA-binding transcriptional activator AppY
Primary source
ECOCYC:EG10050
Locus tag
b0564
See related
ASAP:ABE-0001929
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0556
Summary
appY expression is induced by PO4 starvation and stationary phase. [More information is available at EcoGene: EG10050]. The AppY, "acid phosphatase," transcriptional regulator induces the expression of energy metabolism genes under anaerobiosis, stationary phase, and phosphate starvation. [More information is available at EcoCyc: EG10050].
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Sequence:
NC_000913.3 (583681..584430)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene protein TfaX Neighboring gene omptin family outer membrane protease OmpT Neighboring gene DNA-binding transcriptional activator EnvY

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Isolation, characterization, and nucleotide sequence of appY, a regulatory gene for growth-phase-dependent gene expression in Escherichia coli. Atlung T, et al. J Bacteriol, 1989 Mar. PMID 2537825, Free PMC Article
  2. Gains and unexpected lessons from genome-scale promoter mapping. Shavkunov KS, et al. Nucleic Acids Res, 2009 Aug. PMID 19528070, Free PMC Article
  3. Complete nucleotide sequence and deduced amino acid sequence of the M5 polypeptide gene of Escherichia coli. Kemp EH, et al. Nucleic Acids Res, 1987 May 11. PMID 3295784, Free PMC Article
  4. Location of the ompT gene relative to that of appY on the physical map of the Escherichia coli chromosome. Holmes Z, et al. Mol Gen Genet, 1994 Feb. PMID 8107684
  5. The histone-like protein H-NS acts as a transcriptional repressor for expression of the anaerobic and growth phase activator AppY of Escherichia coli. Atlung T, et al. J Bacteriol, 1996 Jun. PMID 8655536, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. a combination of ArcA and AppY antirepression of IscR function, lower levels of IscR, and weak repression by [2Fe-2S]-IscR leads to increased hyaA promoter expression under anaerobic conditions
    Title: ArcA and AppY antagonize IscR repression of hydrogenase-1 expression under anaerobic conditions, revealing a novel mode of O2 regulation of gene expression in Escherichia coli.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to phosphate starvation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to X-ray IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Preferred Names
DNA-binding transcriptional activator AppY

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    583681..584430
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415096.1 DNA-binding transcriptional activator AppY [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415096.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S7U8P0
    Conserved Domains (2) summary
    smart00342
    Location:152 → 233
    HTH_ARAC; helix_turn_helix, arabinose operon control protein
    cl30840
    Location:1 → 230
    PRK09940; transcriptional regulator YdeO; Provisional
Nucleotide Protein
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