U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

folK 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948792, updated on 30-Jul-2025
Official Symbol
folK
Official Full Name
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase
Primary source
ECOCYC:EG11374
Locus tag
b0142
See related
ASAP:ABE-0000491
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0141
Summary
Reduced folate cofactors are required for the syntheses of various essential cell nutrients. [More information is available at EcoCyc: EG11374].
NEW
Try the new Gene table
Try the new Transcript table
Sequence:
NC_000913.3 (157253..157732, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative fimbrial chaperone YadV Neighboring gene putative fimbrial protein YadN Neighboring gene poly(A) polymerase I Neighboring gene glutamyl-Q tRNA(Asp) synthetase Neighboring gene RNA polymerase-binding transcription factor DksA

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Dynamics of the conformational transitions in the assembling of the Michaelis complex of a bisubstrate enzyme: a (15)N relaxation study of Escherichia coli 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase. Lescop E, et al. Biochemistry, 2009 Jan 20. PMID 19108643
  2. The biosynthesis of folic acid. IX. Purification and properties of the enzymes required for the formation of dihydropteroic acid. Richey DP, et al. J Biol Chem, 1969 Mar 25. PMID 4304228
  3. Crystal structure of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, a potential target for the development of novel antimicrobial agents. Xiao B, et al. Structure, 1999 May. PMID 10378268
  4. 1H, 13C and 15N resonance assignments of Escherichia coli 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase and its complex with MgAMPPCP. Shi G, et al. J Biomol NMR, 1999 Jun. PMID 10427747
  5. 2.0 A X-ray structure of the ternary complex of 7,8-dihydro-6-hydroxymethylpterinpyrophosphokinase from Escherichia coli with ATP and a substrate analogue. Stammers DK, et al. FEBS Lett, 1999 Jul 30. PMID 10452528

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on mature peptide
    Title: Purification and partial characterization of 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase and 7,8-dihydropteroate synthase from Escherichia coli MC4100.
  2. biophysical analysis of conformation and dynamics of the Escherichia coli HPPK apo-enzyme and its binary complex with MgATP
    Title: Loop conformation and dynamics of the Escherichia coli HPPK apo-enzyme and its binary complex with MgATP.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in folic acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in folic acid-containing compound biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in tetrahydrofolate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase
NP_414684.1

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    157253..157732 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414684.1 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase

    See identical proteins and their annotated locations for NP_414684.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A2X1MM44
    Conserved Domains (1) summary
    PRK10239
    Location:1 → 159
    PRK10239; 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.