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ccmF [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948783, updated on 11-Sep-2024

Summary

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Official Symbol
ccmF
Primary source
ECOCYC:EG12054
Locus tag
b2196
See related
ASAP:ABE-0007269
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2188; yejR
Summary
Overexpression causes a decrease in the amount of biofilm formed. [More information is available at EcoGene: EG12054]. CcmF is a membrane protein component of the CcmEFGH holocytochrome c synthetase. [More information is available at EcoCyc: EG12054].
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Genomic context

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Sequence:
NC_000913.3 (2292961..2294904, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional dual regulator NarP Neighboring gene holocytochrome c synthase CcmH component Neighboring gene thiol:disulfide oxidoreductase CcmG Neighboring gene periplasmic heme chaperone Neighboring gene cytochrome c maturation protein D Neighboring gene cytochrome c maturation protein C Neighboring gene cytochrome c maturation protein B Neighboring gene cytochrome c maturation protein A

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Heme ligand identification and redox properties of the cytochrome c synthetase, CcmF. San Francisco B, et al. Biochemistry, 2011 Dec 20. PMID 22066495, Free PMC Article
  2. AtCCMH, an essential component of the c-type cytochrome maturation pathway in Arabidopsis mitochondria, interacts with apocytochrome c. Meyer EH, et al. Proc Natl Acad Sci U S A, 2005 Nov 1. PMID 16236729, Free PMC Article
  3. Probing the heme-binding site of the cytochrome c maturation protein CcmE. Harvat EM, et al. Biochemistry, 2009 Mar 3. PMID 19178152
  4. Evolutionary origins of members of a superfamily of integral membrane cytochrome c biogenesis proteins. Lee JH, et al. Biochim Biophys Acta, 2007 Sep. PMID 17706591
  5. Crystal structures of E. coli CcmG and its mutants reveal key roles of the N-terminal beta-sheet and the fingerprint region. Ouyang N, et al. Proteins, 2006 Dec 1. PMID 17019698

See all (59) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables heme binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables heme transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on diphenols and related substances as donors IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytochrome complex assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cytochrome complex assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in heme transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISM
Inferred from Sequence Model
more info
 PubMed 
located_in plasma membrane NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
holocytochrome c synthase CcmF component

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2292961..2294904 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416700.1 holocytochrome c synthase CcmF component [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416700.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S7KAD5
    Conserved Domains (1) summary
    TIGR00353
    Location:53 → 634
    nrfE; c-type cytochrome biogenesis protein CcmF
Nucleotide Protein
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