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rraB ribonuclease E inhibitor protein B [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948773, updated on 3-Dec-2024
Official Symbol
rraB
Official Full Name
ribonuclease E inhibitor protein B
Primary source
ECOCYC:G7885
Locus tag
b4255
See related
ASAP:ABE-0013936
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4248; yjgD
Summary
RraB binds to the C-terminal half (CTH) of RNase E and interferes with the cleavage of a subset of RNase E target transcripts in vitro and in vivo. [More information is available at EcoCyc: G7885].
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Sequence:
NC_000913.3 (4478473..4478889)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene protein YjgL Neighboring gene ornithine carbamoyltransferase ArgI Neighboring gene putative N-acetyltransferase YjgM Neighboring gene inner membrane protein YjgN

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Preliminary crystallographic analysis of RraB from Escherichia coli. Shen H, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2013 Nov. PMID 24192366, Free PMC Article
  2. Homologous control sites and DNA transcription starts in the related argF and argI genes of Escherichia coli K12. Piette J, et al. EMBO J, 1982. PMID 6329710, Free PMC Article
  3. Transcriptional regulation of the Escherichia coli gene rraB, encoding a protein inhibitor of RNase E. Zhou L, et al. J Bacteriol, 2009 Nov. PMID 19717586, Free PMC Article
  4. Functional implications of the conserved action of regulators of ribonuclease activity. Yeom JH, et al. J Microbiol Biotechnol, 2008 Aug. PMID 18756093
  5. Poly(A)-assisted RNA decay and modulators of RNA stability. Régnier P, et al. Prog Mol Biol Transl Sci, 2009. PMID 19215772

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RraA and RraB have a conserved property to directly act on RNAse E-related enzymes and inhibit their ribonucleolytic activity.
    Title: Inhibitory effects of RraA and RraB on RNAse E-related enzymes imply conserved functions in the regulated enzymatic cleavage of RNA.
  2. expression of RraA or RraB is accompanied by specific changes in degradosome composition--and that these are in turn associated with alterations in RNA decay
    Title: Differential modulation of E. coli mRNA abundance by inhibitory proteins that alter the composition of the degradosome.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables endoribonuclease inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables endoribonuclease inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
enables enzyme binding IEA
Inferred from Electronic Annotation
more info
  
enables enzyme binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ribonuclease inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within mRNA catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of endoribonuclease activity IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
ribonuclease E inhibitor protein B

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4478473..4478889
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418676.1 ribonuclease E inhibitor protein B [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418676.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5B9AQK1
    Conserved Domains (1) summary
    PRK11191
    Location:1 → 138
    PRK11191; ribonuclease E inhibitor RraB
Nucleotide Protein
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