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ridA enamine/imine deaminase, redox-regulated chaperone [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948771, updated on 17-Jul-2025
Official Symbol
ridA
Official Full Name
enamine/imine deaminase, redox-regulated chaperone
Primary source
ECOCYC:G7877
Locus tag
b4243
See related
ASAP:ABE-0013886
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4238; yjgF
Summary
YjgF, RutC, TdcF, YoaB and YjgH are paralogs and members of a highly conserved YjgF family (pfam:PF01042) with diverse mutant phenotypes and unknown molecular function; the family members form homotrimers, some binding 2-ketoglutarate or related compounds. [More information is available at EcoGene: EG12524]. A crystal structure of Escherichia coli YjgF is presented at 1.2 A resolution . [More information is available at EcoCyc: G7877].
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Sequence:
NC_000913.3 (4470527..4470913, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene leader peptide MgtL Neighboring gene Mg(2(+)) importing P-type ATPase Neighboring gene aspartate carbamoyltransferase, PyrI subunit Neighboring gene aspartate carbamoyltransferase catalytic subunit

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Activation of RidA chaperone function by N-chlorination. Müller A, et al. Nat Commun, 2014 Dec 17. PMID 25517874, Free PMC Article
  2. Redox proteomics uncovers peroxynitrite-sensitive proteins that help Escherichia coli to overcome nitrosative stress. Lindemann C, et al. J Biol Chem, 2013 Jul 5. PMID 23696645, Free PMC Article
  3. The ridA gene of E. coli is indirectly regulated by BglG through the transcriptional regulator Lrp in stationary phase. Shukla S, et al. Microbiology (Reading), 2019 Jun. PMID 31063124
  4. Structure-based ligand binding sites of protein p14.5, a member of protein family YER057c/YIL051c/YjgF. Mistiniene E, et al. Int J Biol Macromol, 2005 Oct 30. PMID 16198412
  5. PurF-independent phosphoribosyl amine formation in yjgF mutants of Salmonella enterica utilizes the tryptophan biosynthetic enzyme complex anthranilate synthase-phosphoribosyltransferase. Browne BA, et al. J Bacteriol, 2006 Oct. PMID 16980480, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Enamine/imine deaminase (ridA) is positively regulated by leucine responsive regulatory protein (Lrp). Lrp is indirectly regulated by BglG, which brings about the overexpression of ridA in beta-glucoside operon (bgl)(+) strains during stationary phase. Loss of ridA function in a Bgl(+) background results in a growth retardation in serine-containing media compared to that in a Bgl(-) background.
    Title: The ridA gene of E. coli is indirectly regulated by BglG through the transcriptional regulator Lrp in stationary phase.
  2. Post-translational chlorination activates RidA turning in it to a chaperone.
    Title: Activation of RidA chaperone function by N-chlorination.
  3. N-terminus verified by Edman degradation on mature peptide
    Title: Small genes/gene-products in Escherichia coli K-12.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 2-iminobutanoate deaminase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables deaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables deaminase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables deaminase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables unfolded protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within protein homotrimerization IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to toxic substance IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane HDA PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
enamine/imine deaminase, redox-regulated chaperone
NP_418664.2

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4470527..4470913 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418664.2 enamine/imine deaminase, redox-regulated chaperone

    See identical proteins and their annotated locations for NP_418664.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0AAJ3TZ02, A0AAN3MAC5, Q8XCD0
    Conserved Domains (1) summary
    cl10015
    Location:1 → 127
    YjgF_YER057c_UK114_family; YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no ...
Nucleotide Protein
Heading Accession and Version

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