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chpB endoribonuclease toxin ChpB [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948747, updated on 4-Feb-2026
Official Symbol
chpB
Official Full Name
endoribonuclease toxin ChpB
Primary source
ECOCYC:EG12096
Locus tag
b4225
See related
ASAP:ABE-0013822
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
chpBK; ECK4221; yjfE
Summary
ChpB(ChpBK) is a sequence-specific (ACY) endoribonuclease. [More information is available at EcoGene: EG12096]. ChpB is the toxin component of the ChpB-ChpS toxin-antitoxin system. [More information is available at EcoCyc: EG12096].
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Sequence:
NC_000913.3 (4448692..4449042)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene translocation and assembly module subunit TamA Neighboring gene translocation and assembly module subunit TamB Neighboring gene gamma-glutamylamine cyclotransferase family protein YtfP Neighboring gene ChpS antitoxin of the ChpB-ChpS toxin-antitoxin system Neighboring gene inorganic pyrophosphatase Neighboring gene galactofuranose ABC transporter periplasmic binding protein

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Use of genetically engineered phage to deliver antimicrobial agents to bacteria: an alternative therapy for treatment of bacterial infections. Westwater C, et al. Antimicrob Agents Chemother, 2003 Apr. PMID 12654662, Free PMC Article
  2. Cloning and characterization of the gene encoding inorganic pyrophosphatase of Escherichia coli K-12. Lahti R, et al. J Bacteriol, 1988 Dec. PMID 2848015, Free PMC Article
  3. Structural analysis of the ileR locus of Escherichia coli K12. Weiss DL, et al. J Biol Chem, 1986 Jul 25. PMID 3525538
  4. Mapping and disruption of the chpB locus in Escherichia coli. Masuda Y, et al. J Bacteriol, 1994 Sep. PMID 8083180, Free PMC Article
  5. Functional interactions between chpB and parD, two homologous conditional killer systems found in the Escherichia coli chromosome and in plasmid R1. Santos Sierra S, et al. FEMS Microbiol Lett, 1998 Nov 1. PMID 9812362

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that the signaling molecule extracellular death factor significantly amplifies the endoribonucleolytic activities of both MazF and ChpBK.
    Title: The Escherichia coli extracellular death factor EDF induces the endoribonucleolytic activities of the toxins MazF and ChpBK.
  2. ChpBK is an mRNA interferase from Escherichia coli
    Title: Characterization of ChpBK, an mRNA interferase from Escherichia coli.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA endonuclease activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA endonuclease activity producing 5'-phosphomonoesters, hydrolytic mechanism IDA
Inferred from Direct Assay
more info
 PubMed 
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of cell growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of growth NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of mRNA stability IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in single-species biofilm formation NAS
Non-traceable Author Statement
more info
 PubMed 
Preferred Names
endoribonuclease toxin ChpB
NP_418646.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4448692..4449042
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418646.1 endoribonuclease toxin ChpB

    See identical proteins and their annotated locations for NP_418646.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A8S7EMN9
    Conserved Domains (1) summary
    PRK09812
    Location:1 → 116
    PRK09812; type II toxin-antitoxin system ChpB family toxin
Nucleotide Protein
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