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cysQ 3'(2'),5'-bisphosphate nucleotidase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948728, updated on 3-Dec-2024

Summary

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Official Symbol
cysQ
Official Full Name
3'(2'),5'-bisphosphate nucleotidase
Primary source
ECOCYC:EG10043
Locus tag
b4214
See related
ASAP:ABE-0013786
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
amt; amtA; ECK4210
Summary
CysQ is a main target of lithium toxicity in vivo. [More information is available at EcoGene: EG10043]. CysQ is an adenosine-3',5'-bisphosphate nucleotidase which recycles adenosine-3',5'-bisphosphate (PAP) that is generated during sulfate assimilation (see |FRAME: [More information is available at EcoCyc: EG10043].
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Genomic context

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Sequence:
NC_000913.3 (4436755..4437495)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative transcriptional regulator YtfH Neighboring gene 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase Neighboring gene protein YtfI Neighboring gene PF09695 family protein YtfJ

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Isolation of an ammonium or methylammonium ion transport mutant of Escherichia coli and complementation by the cloned gene. Jayakumar A, et al. J Bacteriol, 1989 Feb. PMID 2536689, Free PMC Article
  2. Ammonium transport in Escherichia coli: localization and nucleotide sequence of the amtA gene. Fabiny JM, et al. J Gen Microbiol, 1991 Apr. PMID 1856684
  3. Transposon Tn5supF-based reverse genetic method for mutational analysis of Escherichia coli with DNAs cloned in lambda phage. Phadnis SH, et al. J Bacteriol, 1991 Jan. PMID 1846153, Free PMC Article
  4. Oligoribonuclease is a common downstream target of lithium-induced pAp accumulation in Escherichia coli and human cells. Mechold U, et al. Nucleic Acids Res, 2006. PMID 16682444, Free PMC Article
  5. A rice HAL2-like gene encodes a Ca(2+)-sensitive 3'(2'),5'-diphosphonucleoside 3'(2')-phosphohydrolase and complements yeast met22 and Escherichia coli cysQ mutations. Peng Z, et al. J Biol Chem, 1995 Dec 8. PMID 7493934

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 3'(2'),5'-bisphosphate nucleotidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3'(2'),5'-bisphosphate nucleotidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 3'(2'),5'-bisphosphate nucleotidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 3'-phosphoadenosine 5'-phosphosulfate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylinositol phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in sulfate assimilation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within sulfate assimilation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sulfur compound metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
3'(2'),5'-bisphosphate nucleotidase
NP_418635.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4436755..4437495
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418635.1 3'(2'),5'-bisphosphate nucleotidase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418635.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2X1PLB2, A0A485JL03, A0A7A6Y1Y0, A0A7L7EBJ4
    Conserved Domains (1) summary
    PRK10931
    Location:1 → 246
    PRK10931; adenosine-3'(2'),5'-bisphosphate nucleotidase; Provisional
Nucleotide Protein
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