U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ulaD 3-keto-L-gulonate-6-phosphate decarboxylase UlaD [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948714, updated on 23-Apr-2026
Official Symbol
ulaD
Official Full Name
3-keto-L-gulonate-6-phosphate decarboxylase UlaD
Primary source
ECOCYC:G7858
Locus tag
b4196
See related
ASAP:ABE-0013729
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4192; sgaH; yjfV
Summary
The ula divergon is comprised of the two divergent ulaGR and ulaABCDEF operons. [More information is available at EcoGene: EG12496]. 3-keto-L-gulonate 6-phosphate decarboxylase is an enzyme in the pathway of anaerobic L-ascorbate degradation. [More information is available at EcoCyc: G7858].
Try the new Gene page
Try the new Transcripts and proteins table
Sequence:
NC_000913.3 (4422186..4422836)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene L-ascorbate specific PTS enzyme IIB component Neighboring gene L-ascorbate specific PTS enzyme IIA component Neighboring gene L-ribulose-5-phosphate 3-epimerase UlaE Neighboring gene L-ribulose-5-phosphate 4-epimerase UlaF Neighboring gene DUF1471 domain-containing protein YjfY

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Evolution of enzymatic activities in the orotidine 5'-monophosphate decarboxylase suprafamily: mechanistic evidence for a proton relay system in the active site of 3-keto-L-gulonate 6-phosphate decarboxylase. Yew WS, et al. Biochemistry, 2004 Jun 1. PMID 15157077
  2. Structural evidence for a 1,2-enediolate intermediate in the reaction catalyzed by 3-keto-L-gulonate 6-phosphate decarboxylase, a member of the orotidine 5'-monophosphate decarboxylase suprafamily. Wise EL, et al. Biochemistry, 2003 Oct 28. PMID 14567674
  3. Homologous (beta/alpha)8-barrel enzymes that catalyze unrelated reactions: orotidine 5'-monophosphate decarboxylase and 3-keto-L-gulonate 6-phosphate decarboxylase. Wise E, et al. Biochemistry, 2002 Mar 26. PMID 11900527
  4. Evolution of enzymatic activities in the orotidine 5'-monophosphate decarboxylase suprafamily: enhancing the promiscuous D-arabino-hex-3-ulose 6-phosphate synthase reaction catalyzed by 3-keto-L-gulonate 6-phosphate decarboxylase. Yew WS, et al. Biochemistry, 2005 Feb 15. PMID 15697206
  5. Evolution of enzymatic activities in the orotidine 5'-monophosphate decarboxylase suprafamily: crystallographic evidence for a proton relay system in the active site of 3-keto-L-gulonate 6-phosphate decarboxylase. Wise EL, et al. Biochemistry, 2004 Jun 1. PMID 15157078

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on complete protein
    Title: '98 Escherichia coli SWISS-2DPAGE database update.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 3-dehydro-L-gulonate-6-phosphate decarboxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3-dehydro-L-gulonate-6-phosphate decarboxylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 3-dehydro-L-gulonate-6-phosphate decarboxylase activity IEA
Inferred from Electronic Annotation
more info
  
enables carboxy-lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables orotidine-5'-phosphate decarboxylase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 'de novo' pyrimidine nucleobase biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in L-ascorbic acid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in L-ascorbic acid catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within L-ascorbic acid catabolic process IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in carbohydrate catabolic process IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
3-keto-L-gulonate-6-phosphate decarboxylase UlaD
NP_418617.1

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4422186..4422836
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418617.1 3-keto-L-gulonate-6-phosphate decarboxylase UlaD

    See identical proteins and their annotated locations for NP_418617.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A3L5H0L2
    Conserved Domains (1) summary
    PRK13306
    Location:1 → 216
    ulaD; 3-dehydro-L-gulonate-6-phosphate decarboxylase
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.