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ulaE L-ribulose-5-phosphate 3-epimerase UlaE [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948712, updated on 23-Apr-2026
Official Symbol
ulaE
Official Full Name
L-ribulose-5-phosphate 3-epimerase UlaE
Primary source
ECOCYC:G7859
Locus tag
b4197
See related
ASAP:ABE-0013732
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4193; sgaU; yjfW
Summary
The ula divergon is comprised of the two divergent ulaGR and ulaABCDEF operons. [More information is available at EcoGene: EG12497]. L-xylulose 5-phosphate 3-epimerase is an enzyme in the pathway of anaerobic L-ascorbate degradation. [More information is available at EcoCyc: G7859].
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Sequence:
NC_000913.3 (4422846..4423700)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene L-ascorbate specific PTS enzyme IIA component Neighboring gene 3-keto-L-gulonate-6-phosphate decarboxylase UlaD Neighboring gene L-ribulose-5-phosphate 4-epimerase UlaF Neighboring gene DUF1471 domain-containing protein YjfY Neighboring gene 30S ribosomal subunit protein S6

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Structure of L-xylulose-5-Phosphate 3-epimerase (UlaE) from the anaerobic L-ascorbate utilization pathway of Escherichia coli: identification of a novel phosphate binding motif within a TIM barrel fold. Shi R, et al. J Bacteriol, 2008 Dec. PMID 18849419, Free PMC Article
  2. Aerobic L-ascorbate metabolism and associated oxidative stress in Escherichia coli. Campos E, et al. Microbiology (Reading), 2007 Oct. PMID 17906139
  3. The gene yjfQ encodes the repressor of the yjfR-X regulon (ula), which is involved in L-ascorbate metabolism in Escherichia coli. Campos E, et al. J Bacteriol, 2002 Nov. PMID 12374842, Free PMC Article
  4. The ascorbate transporter of Escherichia coli. Zhang Z, et al. J Bacteriol, 2003 Apr. PMID 12644495, Free PMC Article
  5. Utilization of L-ascorbate by Escherichia coli K-12: assignments of functions to products of the yjf-sga and yia-sgb operons. Yew WS, et al. J Bacteriol, 2002 Jan. PMID 11741871, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables L-ribulose-5-phosphate 3-epimerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-ribulose-5-phosphate 3-epimerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables L-ribulose-5-phosphate 3-epimerase activity IEA
Inferred from Electronic Annotation
more info
  
enables intramolecular oxidoreductase activity, interconverting aldoses and ketoses IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-ascorbic acid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in L-ascorbic acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within L-ascorbic acid metabolic process IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in monosaccharide metabolic process IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
L-ribulose-5-phosphate 3-epimerase UlaE
NP_418618.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4422846..4423700
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418618.1 L-ribulose-5-phosphate 3-epimerase UlaE

    See identical proteins and their annotated locations for NP_418618.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A8S7JQQ1
    Conserved Domains (1) summary
    PRK13209
    Location:1 → 281
    PRK13209; L-ribulose-5-phosphate 3-epimerase
Nucleotide Protein
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