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ulaR [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948706, updated on 24-Aug-2024

Summary

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Official Symbol
ulaR
Primary source
ASAP:ABE-0013713
Locus tag
b4191
See related
ECOCYC:G7854
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4187; yjfQ
Summary
The ula divergon is comprised of the two divergent ulaGR and ulaABCDEF operons. [More information is available at EcoGene: EG12491]. UlaR is a DNA-binding transcription factor that is expressed constitutively and coordinately represses transcription of a divergent operon (ula) involved in transport and utilization of L-ascorbate catabolism . [More information is available at EcoCyc: G7854].
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Genomic context

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Sequence:
NC_000913.3 (4417698..4418453, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene protease activator YjfN Neighboring gene DUF1471 domain-containing putative lipoprotein BsmA Neighboring gene carboxylesterase Neighboring gene L-ascorbate-6-phosphate lactonase Neighboring gene L-ascorbate specific PTS enzyme IIC component

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Diversification of catalytic activities and ligand interactions in the protein fold shared by the sugar isomerases, eIF2B, DeoR transcription factors, acyl-CoA transferases and methenyltetrahydrofolate synthetase. Anantharaman V, et al. J Mol Biol, 2006 Feb 24. PMID 16376935
  2. Quaternary structural transitions in the DeoR-type repressor UlaR control transcriptional readout from the L-ascorbate utilization regulon in Escherichia coli. Garces F, et al. Biochemistry, 2008 Nov 4. PMID 18844374
  3. Gene regulation at-a-distance in E. coli: new insights. Amouyal M. C R Biol, 2005 Jan. PMID 15714875
  4. Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals. Huerta AM, et al. J Mol Biol, 2003 Oct 17. PMID 14529615
  5. Bioinformatic analyses of the bacterial L-ascorbate phosphotransferase system permease family. Hvorup R, et al. J Mol Microbiol Biotechnol, 2003. PMID 15153772

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. identified the key amino acid residues that mediate L-ascorbate 6-phosphate binding and constructed the first model of regulation of a DeoR family member, establishing the basis of the ula regulon transcription control by UlaR
    Title: Quaternary structural transitions in the DeoR-type repressor UlaR control transcriptional readout from the L-ascorbate utilization regulon in Escherichia coli.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables L-ascorbic acid binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA-templated transcription IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
DNA-binding transcriptional repressor UlaR

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4417698..4418453 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418612.1 DNA-binding transcriptional repressor UlaR [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418612.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A828P3Q3
    Conserved Domains (1) summary
    PRK13509
    Location:1 → 251
    PRK13509; HTH-type transcriptional regulator UlaR
Nucleotide Protein
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