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ulaR DNA-binding transcriptional repressor UlaR [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948706, updated on 30-Jul-2025
Official Symbol
ulaR
Official Full Name
DNA-binding transcriptional repressor UlaR
Primary source
ECOCYC:G7854
Locus tag
b4191
See related
ASAP:ABE-0013713
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4187; yjfQ
Summary
The ula divergon is comprised of the two divergent ulaGR and ulaABCDEF operons. [More information is available at EcoGene: EG12491]. UlaR is a DNA-binding transcription factor that is expressed constitutively and coordinately represses transcription of a divergent operon (ula) involved in transport and utilization of L-ascorbate catabolism . [More information is available at EcoCyc: G7854].
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Sequence:
NC_000913.3 (4417698..4418453, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene protease activator YjfN Neighboring gene DUF1471 domain-containing putative lipoprotein BsmA Neighboring gene carboxylesterase Neighboring gene L-ascorbate-6-phosphate lactonase Neighboring gene L-ascorbate specific PTS enzyme IIC component

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Diversification of catalytic activities and ligand interactions in the protein fold shared by the sugar isomerases, eIF2B, DeoR transcription factors, acyl-CoA transferases and methenyltetrahydrofolate synthetase. Anantharaman V, et al. J Mol Biol, 2006 Feb 24. PMID 16376935
  2. Quaternary structural transitions in the DeoR-type repressor UlaR control transcriptional readout from the L-ascorbate utilization regulon in Escherichia coli. Garces F, et al. Biochemistry, 2008 Nov 4. PMID 18844374
  3. Gene regulation at-a-distance in E. coli: new insights. Amouyal M. C R Biol, 2005 Jan. PMID 15714875
  4. Sigma70 promoters in Escherichia coli: specific transcription in dense regions of overlapping promoter-like signals. Huerta AM, et al. J Mol Biol, 2003 Oct 17. PMID 14529615
  5. Bioinformatic analyses of the bacterial L-ascorbate phosphotransferase system permease family. Hvorup R, et al. J Mol Microbiol Biotechnol, 2003. PMID 15153772

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. identified the key amino acid residues that mediate L-ascorbate 6-phosphate binding and constructed the first model of regulation of a DeoR family member, establishing the basis of the ula regulon transcription control by UlaR
    Title: Quaternary structural transitions in the DeoR-type repressor UlaR control transcriptional readout from the L-ascorbate utilization regulon in Escherichia coli.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables L-ascorbic acid binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ligand-modulated transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA-templated transcription IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
DNA-binding transcriptional repressor UlaR

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4417698..4418453 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418612.1 DNA-binding transcriptional repressor UlaR

    See identical proteins and their annotated locations for NP_418612.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A5B9AQN9
    Conserved Domains (1) summary
    PRK13509
    Location:1 → 251
    PRK13509; HTH-type transcriptional regulator UlaR
Nucleotide Protein
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