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hflK regulator of FtsH protease [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948698, updated on 6-May-2021

Summary

Gene symbol
hflK
Gene description
regulator of FtsH protease
Primary source
ASAP:ABE-0013663
Locus tag
b4174
See related
ECOCYC:EG10436
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4170; hflA; hslY
Summary
Gain-of-function alleles in hflC and hflK inhibit FtsH-mediated degradation of uncomplexed SecY protein and other membrane protein substrates. [More information is available at EcoGene: EG10436]. The HflK-HflC (HflKC) complex interacts with FtsH and regulates (inhibits) proteolysis by FtsH of SecY and lambda cII protein . [More information is available at EcoCyc: EG10436].
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Genomic context

Sequence:
NC_000913.3 (4402038..4403297)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene RNA-binding protein Hfq Neighboring gene ribosome rescue factor HflX Neighboring gene regulator of FtsH protease Neighboring gene DUF2065 domain-containing protein YjeT

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of catalytic activity IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within response to heat IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
part_of membrane protein complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4402038..4403297
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418595.1 regulator of FtsH protease [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418595.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P0ABC7
    Conserved Domains (1) summary
    PRK10930
    Location:1419
    PRK10930; FtsH protease activity modulator HflK
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