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hflK regulator of FtsH protease [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948698, updated on 6-May-2021

Summary

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Gene symbol
hflK
Gene description
regulator of FtsH protease
Primary source
ASAP:ABE-0013663
Locus tag
b4174
See related
ECOCYC:EG10436
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4170; hflA; hslY
Summary
Gain-of-function alleles in hflC and hflK inhibit FtsH-mediated degradation of uncomplexed SecY protein and other membrane protein substrates. [More information is available at EcoGene: EG10436]. The HflK-HflC (HflKC) complex interacts with FtsH and regulates (inhibits) proteolysis by FtsH of SecY and lambda cII protein . [More information is available at EcoCyc: EG10436].
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Genomic context

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Sequence:
NC_000913.3 (4402038..4403297)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene RNA-binding protein Hfq Neighboring gene ribosome rescue factor HflX Neighboring gene regulator of FtsH protease Neighboring gene DUF2065 domain-containing protein YjeT

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Studies on Escherichia coli HflKC suggest the presence of an unidentified λ factor that influences the lysis-lysogeny switch. Bandyopadhyay K, et al. BMC Microbiol, 2011 Feb 17. PMID 21324212, Free PMC Article
  2. The periplasmic domains of Escherichia coli HflKC oligomerize through right-handed coiled-coil interactions. Briere LK, et al. Biochemistry, 2006 Jul 18. PMID 16834335
  3. Efficient isolation of genes by using antibody probes. Young RA, et al. Proc Natl Acad Sci U S A, 1983 Mar. PMID 6219389, Free PMC Article
  4. An analysis of the processes of infection and induction of E. coli mutant hfl-1 by bacteriophage lambda. Belfort M, et al. Virology, 1973 Sep. PMID 4580731
  5. Genetic and biochemical investigation of the Escherichia coli mutant hfl-1 which is lysogenized at high frequency by bacteriophage lambda. Belfort M, et al. J Bacteriol, 1973 Jul. PMID 4352176, Free PMC Article

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. HflKC inhibits the proteolysis of lambdaCII by HflB and hence the overexpression of the former results in an increase in the lysogenic frequency.
    Title: Studies on Escherichia coli HflKC suggest the presence of an unidentified λ factor that influences the lysis-lysogeny switch.
  2. report the first purification of HflK and HflC separately as active and functional proteins and show that each can interact with HflB on its own and each inhibits the proteolysis of lambdaCII
    Title: Escherichia coli HflK and HflC can individually inhibit the HflB (FtsH)-mediated proteolysis of lambdaCII in vitro.
  3. These results demonstrate the importance of right-handed coiled-coil interactions in the oligomerization of HflKC, and a model entailing the formation of a right-handed helical barrel is proposed.
    Title: The periplasmic domains of Escherichia coli HflKC oligomerize through right-handed coiled-coil interactions.
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Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by GO

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of catalytic activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within response to heat IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in integral component of external side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of membrane protein complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
regulator of FtsH protease

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4402038..4403297
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418595.1 regulator of FtsH protease [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418595.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P0ABC7
    Conserved Domains (1) summary
    PRK10930
    Location:1 → 419
    PRK10930; FtsH protease activity modulator HflK
Nucleotide Protein
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Other Literature Sources
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Research Materials
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