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purA adenylosuccinate synthetase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948695, updated on 3-Dec-2024

Summary

Official Symbol
purA
Official Full Name
adenylosuccinate synthetase
Primary source
ECOCYC:EG10790
Locus tag
b4177
See related
ASAP:ABE-0013672
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
adeK; ECK4173
Summary
Adenylosuccinate synthetase catalyzes the first committed step toward the de novo synthesis of AMP. [More information is available at EcoCyc: EG10790].
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Genomic context

Sequence:
NC_000913.3 (4404687..4405985)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene regulator of FtsH protease Neighboring gene DUF2065 domain-containing protein YjeT Neighboring gene DNA-binding transcriptional regulator NsrR Neighboring gene RNase R

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables adenylosuccinate synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables adenylosuccinate synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables adenylosuccinate synthase activity IEA
Inferred from Electronic Annotation
more info
 
enables guanosine tetraphosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol HDA PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane HDA PubMed 

General protein information

Preferred Names
adenylosuccinate synthetase
NP_418598.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4404687..4405985
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418598.1 adenylosuccinate synthetase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418598.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5B9AN30, A0A6C9QG12
    Conserved Domains (1) summary
    PRK01117
    Location:2432
    PRK01117; adenylosuccinate synthetase; Provisional