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nsrR DNA-binding transcriptional regulator NsrR [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948693, updated on 19-Sep-2024

Summary

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Official Symbol
nsrR
Official Full Name
DNA-binding transcriptional regulator NsrR
Primary source
ECOCYC:EG11212
Locus tag
b4178
See related
ASAP:ABE-0013676
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4174; yjeB
Summary
NsrR is a weak regulator of tehA. tehA clones may titrate out NsrR. [More information is available at EcoGene: EG11212]. NsrR , the "nitrite-sensitive repressor" , regulates genes involved in cell protection against nitric oxide (NO) . [More information is available at EcoCyc: EG11212].
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Genomic context

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Sequence:
NC_000913.3 (4406190..4406615)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF2065 domain-containing protein YjeT Neighboring gene adenylosuccinate synthetase Neighboring gene RNase R Neighboring gene 23S rRNA 2'-O-ribose G2251 methyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Inefficient translation of nsrR constrains behaviour of the NsrR regulon in Escherichia coli. Chhabra S, et al. Microbiology (Reading), 2015 Oct. PMID 26239124
  2. The transcriptional repressor protein NsrR senses nitric oxide directly via a [2Fe-2S] cluster. Tucker NP, et al. PLoS One, 2008. PMID 18989365, Free PMC Article
  3. Expression of nitrite reductase in Nitrosomonas europaea involves NsrR, a novel nitrite-sensitive transcription repressor. Beaumont HJ, et al. Mol Microbiol, 2004 Oct. PMID 15458412
  4. In vivo [Fe-S] cluster acquisition by IscR and NsrR, two stress regulators in Escherichia coli. Vinella D, et al. Mol Microbiol, 2013 Feb. PMID 23320508
  5. Down-regulation of the Escherichia coli K-12 nrf promoter by binding of the NsrR nitric oxide-sensing transcription repressor to an upstream site. Browning DF, et al. J Bacteriol, 2010 Jul. PMID 20472787, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The authors show that nsrR is expressed from a strong promoter, but that its translation is extremely inefficient, leading to a low cellular NsrR concentration.
    Title: Inefficient translation of nsrR constrains behaviour of the NsrR regulon in Escherichia coli.
  2. Fe-S clusters directed at the apo-NsrR and apo-IscR proteins are built on either of the two scaffolds, IscU or SufB.
    Title: In vivo [Fe-S] cluster acquisition by IscR and NsrR, two stress regulators in Escherichia coli.
  3. Activation of the Escherichia coli K-12 nrf promoter is downregulated by the nitric oxide-sensitive NsrR protein together with the nucleoid-associated protein IHF.
    Title: Down-regulation of the Escherichia coli K-12 nrf promoter by binding of the NsrR nitric oxide-sensing transcription repressor to an upstream site.
  4. NsrR is a negative regulator of motility in E. coli K12.
    Title: NsrR targets in the Escherichia coli genome: new insights into DNA sequence requirements for binding and a role for NsrR in the regulation of motility.
  5. Suppression of growth defects in E coli lacking phosphorolytic ribonnucleases was found to be controlled by nrR, a nitric oxide (NO)-sensitive transcriptional repressor.
    Title: Identification and characterization of growth suppressors of Escherichia coli strains lacking phosphorolytic ribonucleases.
  6. Overexpression of NsrR represses the tynA and feaB promoters and severely retards growth on phenylethylamine.
    Title: Escherichia coli NsrR regulates a pathway for the oxidation of 3-nitrotyramine to 4-hydroxy-3-nitrophenylacetate.
  7. Identification of binding sites for the nitric oxide-sensitive transcriptional regulator NsrR.
    Title: Genome-wide identification of binding sites for the nitric oxide-sensitive transcriptional regulator NsrR.
  8. NsrR represses the hybrid cluster protein, HCP, and nrfA promoter that directs the expression of the periplasmic respiratory nitrite reductase.
    Title: The NsrR regulon of Escherichia coli K-12 includes genes encoding the hybrid cluster protein and the periplasmic, respiratory nitrite reductase.
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General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 2 iron, 2 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables double-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
DNA-binding transcriptional regulator NsrR

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4406190..4406615
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418599.1 DNA-binding transcriptional regulator NsrR [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418599.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S0G4A2
    Conserved Domains (1) summary
    PRK11014
    Location:1 → 141
    PRK11014; HTH-type transcriptional repressor NsrR
Nucleotide Protein
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