U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

tsaE N(6)-L-threonylcarbamoyladenine synthase, TsaE subunit [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948684, updated on 19-Nov-2025
Official Symbol
tsaE
Official Full Name
N(6)-L-threonylcarbamoyladenine synthase, TsaE subunit
Primary source
ECOCYC:EG11757
Locus tag
b4168
See related
ASAP:ABE-0013649
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4164; yjeE
Summary
yjeE is non-essential in the presence of multicopy rstA (Campbell, 2007). [More information is available at EcoGene: EG11757]. YjeE is essential for growth in complex media . [More information is available at EcoCyc: EG11757].
NEW
Try the new Gene table
Try the new Transcript table
Sequence:
NC_000913.3 (4395585..4396046)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene tRNA-Gly Neighboring gene uncharacterized protein YjeV Neighboring gene epoxyqueuosine reductase Neighboring gene NAD(P)HX epimerase/NAD(P)HX dehydratase Neighboring gene N-acetylmuramoyl-L-alanine amidase B Neighboring gene DNA mismatch repair protein MutL Neighboring gene tRNA dimethylallyltransferase

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Probing the active site of YjeE: a vital Escherichia coli protein of unknown function. Allali-Hassani A, et al. Biochem J, 2004 Dec 15. PMID 15324301, Free PMC Article
  2. Known bioactive small molecules probe the function of a widely conserved but enigmatic bacterial ATPase, YjeE. Mangat CS, et al. Chem Biol, 2008 Dec 22. PMID 19101473
  3. The ATP-mediated formation of the YgjD-YeaZ-YjeE complex is required for the biosynthesis of tRNA t6A in Escherichia coli. Zhang W, et al. Nucleic Acids Res, 2015 Feb 18. PMID 25578970, Free PMC Article
  4. Isolation of the rstA gene as a multicopy suppressor of YjeE, an essential ATPase of unknown function in Escherichia coli. Campbell TL, et al. J Bacteriol, 2007 Apr. PMID 17293428, Free PMC Article
  5. The ATPase activity of an 'essential' Bacillus subtilis enzyme, YdiB, is required for its cellular function and is modulated by oligomerization. Karst JC, et al. Microbiology (Reading), 2009 Mar. PMID 19246765

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ADP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in maintenance of translational fidelity NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within protein autophosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in tRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA threonylcarbamoyladenosine modification IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within tRNA threonylcarbamoyladenosine modification IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in tRNA threonylcarbamoyladenosine modification IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in tRNA threonylcarbamoyladenosine modification IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of EKC/KEOPS complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
N(6)-L-threonylcarbamoyladenine synthase, TsaE subunit
NP_418589.1

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4395585..4396046
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418589.1 N(6)-L-threonylcarbamoyladenine synthase, TsaE subunit

    See identical proteins and their annotated locations for NP_418589.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0H3ETE2, A0A0H3Q2Z2, A0A1D7PTI0, A0A377ATL9, A0A5B9ALY2, A0A8E0KSJ5, A0AAN3IMJ0, A0AAN3V1L9, A0AAN4NP42, A0ABC8A1N6, B1LQI8
    Conserved Domains (1) summary
    PRK10646
    Location:1 → 153
    PRK10646; tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.