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ampC beta-lactamase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948669, updated on 3-Dec-2024
Official Symbol
ampC
Official Full Name
beta-lactamase
Primary source
ECOCYC:EG10040
Locus tag
b4150
See related
ASAP:ABE-0013592
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ampA; ECK4146
Summary
False positive lipoprotein prediction. [More information is available at EcoGene: EG10040]. The ampC -lactamase gene encodes a serine cephalosporinase . [More information is available at EcoCyc: EG10040].
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Sequence:
NC_000913.3 (4377811..4378944, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene bacteriolytic entericidin B lipoprotein Neighboring gene guanidinium exporter Neighboring gene outer membrane lipoprotein Blc Neighboring gene fumarate reductase membrane protein FrdD Neighboring gene fumarate reductase membrane protein FrdC

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The acyl-enzyme mechanism of beta-lactamase action. The evidence for class C Beta-lactamases. Knott-Hunziker V, et al. Biochem J, 1982 Nov 1. PMID 6818947, Free PMC Article
  2. Disc methods for detecting AmpC {beta}-lactamase-producing clinical isolates of Escherichia coli and Klebsiella pneumoniae. Brenwald NP, et al. J Antimicrob Chemother, 2005 Sep. PMID 16087656
  3. Increase in ampC promoter strength due to mutations and deletion of the attenuator in a clinical isolate of cefoxitin-resistant Escherichia coli as determined by RT-PCR. Tracz DM, et al. J Antimicrob Chemother, 2005 May. PMID 15761065
  4. New method for laboratory detection of AmpC beta-lactamases in Escherichia coli and Klebsiella pneumoniae. Nasim K, et al. J Clin Microbiol, 2004 Oct. PMID 15472344, Free PMC Article
  5. Aza-boronic acids as non-beta-lactam inhibitors of AmpC-beta-lactamase. Buzzoni V, et al. Bioorg Med Chem Lett, 2004 Aug 2. PMID 15225711

See all (59) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. High-level ceftazidime/avibactam resistance in Escherichia coli conferred by the novel plasmid-mediated beta-lactamase CMY-185 variant.
    Title: High-level ceftazidime/avibactam resistance in Escherichia coli conferred by the novel plasmid-mediated β-lactamase CMY-185 variant.
  2. Clonal Relationship and Resistance Profiles Among ESBL-Producing Escherichia coli.
    Title: Clonal Relationship and Resistance Profiles Among ESBL-Producing Escherichia coli.
  3. Surveillance of OXA-244-producing Escherichia coli and epidemiologic investigation of cases, Denmark, January 2016 to August 2019.
    Title: Surveillance of OXA-244-producing Escherichia coli and epidemiologic investigation of cases, Denmark, January 2016 to August 2019.
  4. Given the considerable spatial, temporal, and ecological factors, heterogeneity, which affects emergency response, persistence, and dissemination of genetic determinants that confer microorganisms their resistance to antibiotics, several authors claim that antibiotics' resistance must be perceived as an ecological problem. The aim of this study was to determine the prevalence of broad-spectrum bla genes, not only Extended
    Title: ESBL and AmpC β-Lactamases in Clinical Strains of Escherichia coli from Serra da Estrela, Portugal.
  5. These findings demonstrate that animal-based food products in HCMC represent a major reservoir of ESBL/pAmpC-producing E. coli.
    Title: Dissemination of Extended-Spectrum β-Lactamase- and AmpC β-Lactamase-Producing Escherichia coli within the Food Distribution System of Ho Chi Minh City, Vietnam.
  6. Recently, high-level AmpC production has also been seen in new species such as Escherichia coli via plasmid acquisition.
    Title: Clinical management of infections caused by Enterobacteriaceae that express extended-spectrum β-lactamase and AmpC enzymes.
  7. the majority of the strains of E. coli with AmpC-susceptibility pattern are pAmpC positive, although the association of extended-spectrum beta-lactamases (ESBL) and pAmpC is unusual.
    Title: Diversity of bla genes and low incidence of CTX-M in plasmid-mediated AmpC-producing Escherichia coli clinical isolates.
  8. A high prevalence of birds carries extended spectrumBL(ESBL)/AmpC-producing E. coli at Dutch broiler farms and a high prevalence of ESBL/AmpC-producing E. coli in farmers.
    Title: Extended-spectrum-β-lactamase- and AmpC-β-lactamase-producing Escherichia coli in Dutch broilers and broiler farmers.
  9. Extended-spectrum beta-lactamase-producing Escherichia coli from retail chicken meat and humans: comparison of strains, plasmids, resistance genes, and virulence factors.
    Title: Extended-spectrum β-lactamase-producing Escherichia coli from retail chicken meat and humans: comparison of strains, plasmids, resistance genes, and virulence factors.
  10. determined structure of ampC K67R mutant by X-ray crystallography in apo & transition state-analog complexed forms; results suggest arginine side chain is unable to play the same catalytic role as Lys67 in either the acylation or deacylation reactions
    Title: Re-examining the role of Lys67 in class C beta-lactamase catalysis.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables beta-lactamase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables beta-lactamase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in antibiotic catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in antibiotic catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in response to antibiotic IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in outer membrane-bounded periplasmic space IEA
Inferred from Electronic Annotation
more info
  
located_in periplasmic space IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
beta-lactamase
NP_418574.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4377811..4378944 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418574.1 beta-lactamase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418574.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A0M4JL69, A0A0M4K1N3, A0A6M9WXB7
    Conserved Domains (1) summary
    PRK11289
    Location:1 → 377
    ampC; beta-lactamase/D-alanine carboxypeptidase; Provisional
Nucleotide Protein
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Gene LinkOut

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