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aspA aspartate ammonia-lyase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948658, updated on 6-May-2021

Summary

Gene symbol
aspA
Gene description
aspartate ammonia-lyase
Primary source
ASAP:ABE-0013551
Locus tag
b4139
See related
ECOCYC:EG10095
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4133
Summary
Tetrameric enzyme. [More information is available at EcoGene: EG10095]. Aspartate-ammonia lyase (aspartase) carries out the reversible conversion of L-aspartate to fumarate and ammonia. [More information is available at EcoCyc: EG10095].
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Genomic context

Sequence:
NC_000913.3 (4366891..4368327, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene thiol-disulfide exchange protein DsbD Neighboring gene copper binding protein CutA Neighboring gene C4-dicarboxylate transporter DcuA Neighboring gene protein FxsA Neighboring gene L-methionine/branched chain amino acid exporter

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables aspartate ammonia-lyase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables aspartate ammonia-lyase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables aspartate ammonia-lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in aspartate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within aspartate metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within aspartate metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
aspartate ammonia-lyase
NP_418562.4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4366891..4368327 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418562.4 aspartate ammonia-lyase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418562.4

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P0AC38
    Conserved Domains (1) summary
    PRK12273
    Location:1473
    aspA; aspartate ammonia-lyase; Provisional
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