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cadC DNA-binding transcriptional activator CadC [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948653, updated on 19-Nov-2025
Official Symbol
cadC
Official Full Name
DNA-binding transcriptional activator CadC
Primary source
ECOCYC:EG10133
Locus tag
b4133
See related
ASAP:ABE-0013532
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4127
Summary
cadC transcription is repressed by multicopy leuO. [More information is available at EcoGene: EG10133]. CadC is a metal-sensitive transcriptional activator that regulates the expression of genes involved in cadaverine synthesis and excretion under low external pH and high concentrations of lysine . [More information is available at EcoCyc: EG10133].
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Sequence:
NC_000913.3 (4360396..4361934, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene lysine decarboxylase 1 Neighboring gene lysine:cadaverine antiporter Neighboring gene pseudo Neighboring gene tRNA-Phe

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Structural and Functional Analysis of the Signal-Transducing Linker in the pH-Responsive One-Component System CadC of Escherichia coli. Buchner S, et al. J Mol Biol, 2015 Jul 31. PMID 25979249
  2. Detection and function of an intramolecular disulfide bond in the pH-responsive CadC of Escherichia coli. Tetsch L, et al. BMC Microbiol, 2011 Apr 12. PMID 21486484, Free PMC Article
  3. Interference of the CadC regulator in the arginine-dependent acid resistance system of Shigella and enteroinvasive E. coli. Casalino M, et al. Int J Med Microbiol, 2010 Jun. PMID 19959396
  4. CadC is the preferential target of a convergent evolution driving enteroinvasive Escherichia coli toward a lysine decarboxylase-defective phenotype. Casalino M, et al. Infect Immun, 2003 Oct. PMID 14500464, Free PMC Article
  5. Structure-function analysis of the DNA-binding domain of a transmembrane transcriptional activator. Schlundt A, et al. Sci Rep, 2017 Apr 21. PMID 28432336, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Here, the authors present the crystal structure of the CadC DNA-binding domain (DBD) and show that it adopts a winged helix-turn-helix fold.
    Title: Structure-function analysis of the DNA-binding domain of a transmembrane transcriptional activator.
  2. The disordered CadC linker is required for transducing the pH-dependent response of the periplasmic sensor into a structural rearrangement that facilitates dimerization of the cytoplasmic CadC DNA-binding domain.
    Title: Structural and Functional Analysis of the Signal-Transducing Linker in the pH-Responsive One-Component System CadC of Escherichia coli.
  3. Upon induction, lysine-dependent conformational changes in LysP transduce the lysine signal via a direct conformational coupling to CadC without resolving the interaction completely.
    Title: New insights into the interplay between the lysine transporter LysP and the pH sensor CadC in Escherichia coli.
  4. Substitution of Cys208 and/or Cys272 by alanine resulted in CadC derivatives that were active in response to only one stimulus, either lysine or pH 5.8.
    Title: Detection and function of an intramolecular disulfide bond in the pH-responsive CadC of Escherichia coli.
  5. Results describe the crystal structure of CadC(pd) (residues 188-512) solved at a resolution of 1.8 A via multiple wavelength anomalous dispersion (MAD) using a ReCl(6)(2-) derivative.
    Title: Crystal structure of the sensory domain of Escherichia coli CadC, a member of the ToxR-like protein family.
  6. The authors present evidence that CadC negatively regulates the expression of the arginine-dependent adaptive acid-resistance system (AR3), encoded by the adi locus while it has no effect on the expression of AR1 and AR2 systems.
    Title: Interference of the CadC regulator in the arginine-dependent acid resistance system of Shigella and enteroinvasive E. coli.
  7. The results suggest a model according to which CadC is inactivated by an interaction with LysP at a low external lysine concentration.
    Title: The membrane-integrated transcriptional activator CadC of Escherichia coli senses lysine indirectly via the interaction with the lysine permease LysP.
  8. The transcriptional activator CadC in Escherichia coli, a member of the ToxR-like proteins, activates transcription of the cadBA operon encoding the lysine decarboxylase CadA and the lysine-cadaverine antiporter CadB
    Title: CadC-mediated activation of the cadBA promoter in Escherichia coli.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphorelay response regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription cis-regulatory region binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in phosphorelay signal transduction system IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
part_of protein-DNA complex IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
DNA-binding transcriptional activator CadC

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4360396..4361934 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418557.1 DNA-binding transcriptional activator CadC

    See identical proteins and their annotated locations for NP_418557.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A8T6B455
    Conserved Domains (1) summary
    PRK10153
    Location:1 → 512
    PRK10153; DNA-binding transcriptional activator CadC; Provisional
Nucleotide Protein
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