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fadR DNA-binding transcriptional dual regulator FadR [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948652, updated on 3-Dec-2024

Summary

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Official Symbol
fadR
Official Full Name
DNA-binding transcriptional dual regulator FadR
Primary source
ECOCYC:EG10281
Locus tag
b1187
See related
ASAP:ABE-0003988
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
dec; ECK1175; ole; oleR; thdB
Summary
The fad genes are induced and fabAB, iclR are repressed by long chain acyl-CoA thioesters binding to and releasing FadR from the DNA. [More information is available at EcoGene: EG10281]. FadR is a dual DNA-binding transcriptional regulator for fatty acid metabolism. [More information is available at EcoCyc: EG10281].
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Genomic context

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Sequence:
NC_000913.3 (1234938..1235657)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene protein thiol:quinone oxidoreductase DsbB Neighboring gene Na(+):H(+) antiporter NhaB Neighboring gene PF04293 family protein YcgB Neighboring gene D-amino acid dehydrogenase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Novel DNA-Sepharose purification of the FadR transcription factor. DiRusso C, et al. J Chromatogr A, 1994 Aug 12. PMID 7951981
  2. The structural basis of acyl coenzyme A-dependent regulation of the transcription factor FadR. van Aalten DM, et al. EMBO J, 2001 Apr 17. PMID 11296236, Free PMC Article
  3. Crystallization and X-ray diffraction studies of the fatty-acid responsive transcription factor FadR from Escherichia coli. van Aalten DM, et al. Acta Crystallogr D Biol Crystallogr, 2000 Apr. PMID 10739923
  4. Fatty acyl-CoA binding domain of the transcription factor FadR. Characterization by deletion, affinity labeling, and isothermal titration calorimetry. DiRusso CC, et al. J Biol Chem, 1998 Dec 11. PMID 9837950
  5. Metabolic routing towards polyhydroxyalkanoic acid synthesis in recombinant Escherichia coli (fadR): inhibition of fatty acid beta-oxidation by acrylic acid. Qi Q, et al. FEMS Microbiol Lett, 1998 Oct 1. PMID 9785457

See all (68) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Escherichia coli FadR transcription factor: Too much of a good thing?
    Title: The Escherichia coli FadR transcription factor: Too much of a good thing?
  2. Elimination of the guanidine side chain of the CoA moiety binding site severely diminished the ability of FadR to bind the acyl-CoA effector.
    Title: Modulation of FadR binding capacity for acyl-CoA fatty acids through structure-guided mutagenesis.
  3. Structural analyses of FadR protein indicated that the hydrophobic interaction amongst the three amino acids (W60, F74 and W75) is critical for its DNA-binding ability.
    Title: A new glimpse of FadR-DNA crosstalk revealed by deep dissection of the E. coli FadR regulatory protein.
  4. FadR activates the transcription of Fatty Acid synthesis genes.
    Title: Reassessment of the Genetic Regulation of Fatty Acid Synthesis in Escherichia coli: Global Positive Control by the Dual Functional Regulator FadR.
  5. Regulates FadH together with ArcA-ARcB systen and the cyclic AMP receptor protein-cyclic AMP.
    Title: Overlapping repressor binding sites result in additive regulation of Escherichia coli FadH by FadR and ArcA.
  6. N-terminus verified by Edman degradation on mature peptide
    Title: Characterization of FadR, a global transcriptional regulator of fatty acid metabolism in Escherichia coli. Interaction with the fadB promoter is prevented by long chain fatty acyl coenzyme A.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables fatty-acyl-CoA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
acts_upstream_of_or_within positive regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in positive regulation of fatty acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of fatty acid metabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
DNA-binding transcriptional dual regulator FadR

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1234938..1235657
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415705.1 DNA-binding transcriptional dual regulator FadR [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415705.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A192CMN6
    Conserved Domains (1) summary
    PRK04984
    Location:1 → 239
    PRK04984; fatty acid metabolism transcriptional regulator FadR
Nucleotide Protein
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