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lysU lysine--tRNA ligase/Ap4A synthetase/Ap3A synthetase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948645, updated on 3-Dec-2024

Summary

Official Symbol
lysU
Official Full Name
lysine--tRNA ligase/Ap4A synthetase/Ap3A synthetase
Primary source
ECOCYC:EG10553
Locus tag
b4129
See related
ASAP:ABE-0013520
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4123
Summary
The lysyl-tRNA synthetase LysU is a member of the family of aminoacyl tRNA synthetases, which interpret the genetic code by covalently linking amino acids to their specific tRNA molecules. [More information is available at EcoCyc: EG10553].
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Genomic context

Sequence:
NC_000913.3 (4353200..4354717, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene antitoxin of the GhoTS toxin-antitoxin system Neighboring gene toxin of the GhoTS toxin-antitoxin system Neighboring gene dipeptide/tripeptide:H(+) symporter DtpC Neighboring gene lysine decarboxylase 1

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables catalytic activity, acting on a nucleic acid IEA
Inferred from Electronic Annotation
more info
 
enables ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables lysine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables lysine-tRNA ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables lysine-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables lysine-tRNA ligase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
enables tRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in RNA capping IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to heat IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lysyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in lysyl-tRNA aminoacylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in lysyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within lysyl-tRNA aminoacylation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within tRNA aminoacylation for protein translation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in translation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane HDA PubMed 

General protein information

Preferred Names
lysine--tRNA ligase/Ap4A synthetase/Ap3A synthetase
NP_418553.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4353200..4354717 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418553.1 lysine--tRNA ligase/Ap4A synthetase/Ap3A synthetase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418553.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376ME58, A0A3P5E0C6, A0AAN5FB39
    Conserved Domains (1) summary
    PRK12445
    Location:1505
    PRK12445; lysyl-tRNA synthetase; Reviewed