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fumB [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948642, updated on 11-Sep-2024

Summary

Official Symbol
fumB
Primary source
ECOCYC:EG10357
Locus tag
b4122
See related
ASAP:ABE-0013501
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4115
Summary
FumB is required for anaerobic D-tartrate utilization and fumB mutants have reduced D-tartrate dehydratase activity (Kim, 2007). [More information is available at EcoGene: EG10357]. One of three isozymes in Escherichia coli, fumarase B is a Class I fumarase. [More information is available at EcoCyc: EG10357].
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Genomic context

Sequence:
NC_000913.3 (4345680..4347326, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene melibiose:H(+)/Na(+)/Li(+) symporter Neighboring gene DUF2238 domain-containing inner membrane protein YjdF Neighboring gene anaerobic C4-dicarboxylate transporter DcuB Neighboring gene DNA-binding transcriptional activator DcuR Neighboring gene sensor histidine kinase DcuS

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IDA
Inferred from Direct Assay
more info
PubMed 
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
enables D(-)-tartrate dehydratase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables D(-)-tartrate dehydratase activity IEA
Inferred from Electronic Annotation
more info
 
enables D(-)-tartrate dehydratase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables fumarate hydratase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables fumarate hydratase activity IEA
Inferred from Electronic Annotation
more info
 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol HDA PubMed 

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4345680..4347326 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418546.1 fumarase B [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418546.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6N8QYQ4
    Conserved Domains (1) summary
    PRK15391
    Location:1548
    PRK15391; class I fumarate hydratase