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dcuR DNA-binding transcriptional activator DcuR [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948640, updated on 3-Dec-2024
Official Symbol
dcuR
Official Full Name
DNA-binding transcriptional activator DcuR
Primary source
ECOCYC:G7826
Locus tag
b4124
See related
ASAP:ABE-0013507
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4117; yjdG
Summary
dcuSR operon is repressed by nitrate via the NarXL system. [More information is available at EcoGene: EG12464]. [More information is available at EcoCyc: G7826].
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Sequence:
NC_000913.3 (4349315..4350034, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene fumarase B Neighboring gene anaerobic C4-dicarboxylate transporter DcuB Neighboring gene sensor histidine kinase DcuS Neighboring gene PF06902 family protein YjdI Neighboring gene putative N-acetyltransferase YjdJ

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Tight Complex Formation of the Fumarate Sensing DcuS-DcuR Two-Component System at the Membrane and Target Promoter Search by Free DcuR Diffusion. Gencheva S, et al. mSphere, 2022 Aug 31. PMID 35862816, Free PMC Article
  2. Function of DcuS from Escherichia coli as a fumarate-stimulated histidine protein kinase in vitro. Janausch IG, et al. J Biol Chem, 2002 Oct 18. PMID 12167640
  3. Phosphorylation and DNA binding of the regulator DcuR of the fumarate-responsive two-component system DcuSR of Escherichia coli. Janausch IG, et al. Microbiology (Reading), 2004 Apr. PMID 15073297
  4. Polar localization of a tripartite complex of the two-component system DcuS/DcuR and the transporter DctA in Escherichia coli depends on the sensor kinase DcuS. Scheu PD, et al. PLoS One, 2014. PMID 25549248, Free PMC Article
  5. Fumarate regulation of gene expression in Escherichia coli by the DcuSR (dcuSR genes) two-component regulatory system. Zientz E, et al. J Bacteriol, 1998 Oct. PMID 9765574, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Regulation of Aerobic Succinate Transporter dctA of E. coli by cAMP-CRP, DcuS-DcuR, and EIIAGlc: Succinate as a Carbon Substrate and Signaling Molecule.
    Title: Regulation of Aerobic Succinate Transporter dctA of E. coli by cAMP-CRP, DcuS-DcuR, and EIIAGlc: Succinate as a Carbon Substrate and Signaling Molecule.
  2. Tight Complex Formation of the Fumarate Sensing DcuS-DcuR Two-Component System at the Membrane and Target Promoter Search by Free DcuR Diffusion.
    Title: Tight Complex Formation of the Fumarate Sensing DcuS-DcuR Two-Component System at the Membrane and Target Promoter Search by Free DcuR Diffusion.
  3. DcuS is required for location of DctA and DcuR at the poles and formation of tripartite DctA/DcuS/DcuR sensor/regulator complexes.
    Title: Polar localization of a tripartite complex of the two-component system DcuS/DcuR and the transporter DctA in Escherichia coli depends on the sensor kinase DcuS.
  4. DcuS/DcuR modulating citA and citB expression.
    Title: CitA/CitB two-component system regulating citrate fermentation in Escherichia coli and its relation to the DcuS/DcuR system in vivo.
  5. The transcription of structural genes is activated by the DcuS-DcuR two-component system in response to fumarate or its dicarboxylate precursors.
    Title: Hierarchical control of anaerobic gene expression in Escherichia coli K-12: the nitrate-responsive NarX-NarL regulatory system represses synthesis of the fumarate-responsive DcuS-DcuR regulatory system.
  6. Study analyzed promoters of the dcuS-R operon to elucidate the transcriptional regulation system and found a new internal promoter within the dcuS gene that is regulated by the transcriptional regulator, CRP-cAMP, in both aerobic and anaerobic conditions.
    Title: Expression of Escherichia coli DcuS-R two-component regulatory system is regulated by the secondary internal promoter which is activated by CRP-cAMP.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphorelay response regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA-templated transcription IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within phosphorelay signal transduction system IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phosphorelay signal transduction system IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
DNA-binding transcriptional activator DcuR

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4349315..4350034 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418548.1 DNA-binding transcriptional activator DcuR [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418548.1

    Status: PROVISIONAL

    Conserved Domains (1) summary
    PRK10430
    Location:1 → 239
    PRK10430; two-component system response regulator DcuR
Nucleotide Protein
Heading Accession and Version

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