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adiA arginine decarboxylase, degradative [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948638, updated on 17-Jul-2025
Official Symbol
adiA
Official Full Name
arginine decarboxylase, degradative
Primary source
ECOCYC:EG11501
Locus tag
b4117
See related
ASAP:ABE-0013483
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
adi; ECK4110
Summary
AdiA is homologous to CadA, SpeC, and SpeF. [More information is available at EcoGene: EG11501]. Escherichia coli contains two types of arginine decarboxylase. [More information is available at EcoCyc: EG11501].
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Sequence:
NC_000913.3 (4338254..4340521, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene arginine:agmatine antiporter Neighboring gene DNA-binding transcriptional activator AdiY Neighboring gene DNA-binding transcriptional dual regulator MelR Neighboring gene alpha-galactosidase

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Crystal structure of the acid-induced arginine decarboxylase from Escherichia coli: reversible decamer assembly controls enzyme activity. Andréll J, et al. Biochemistry, 2009 May 12. PMID 19298070
  2. High-performance liquid chromatography method with radiochemical detection for measurement of nitric oxide synthase, arginase, and arginine decarboxylase activities. Volke A, et al. Methods Find Exp Clin Pharmacol, 2006 Jan-Feb. PMID 16541190
  3. Argenine decarboxylase from Escherichia coli. I. Purification and specificity for substrates and coenzyme. Blethen SL, et al. J Biol Chem, 1968 Apr 25. PMID 4870599
  4. Nutritional requirements for the formation of arginine decarboxylase in Escherichia coli. MELNYKOVYCH G, et al. J Bacteriol, 1958 Nov. PMID 13598712, Free PMC Article
  5. Purification and study of L-arginine decarboxylase from Escherichia coli B. SHER IH, et al. Arch Biochem Biophys, 1954 Dec. PMID 13218705

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on complete protein
    Title: Chemical properties of Escherichia coli lysine decarboxylase including a segment of its pyridoxal 5'-phosphate binding site.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables arginine decarboxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables arginine decarboxylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables carboxy-lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables pyridoxal phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pyridoxal phosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in L-arginine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within L-arginine catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within intracellular pH elevation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
arginine decarboxylase, degradative
NP_418541.2

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4338254..4340521 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418541.2 arginine decarboxylase, degradative

    See identical proteins and their annotated locations for NP_418541.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1X3J976, A0AAN3V8M8, W8SXR0
    Conserved Domains (1) summary
    PRK15029
    Location:1 → 755
    PRK15029; arginine decarboxylase; Provisional
Nucleotide Protein
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