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melA alpha-galactosidase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948636, updated on 6-Jun-2024

Summary

Gene symbol
melA
Gene description
alpha-galactosidase
Primary source
ASAP:ABE-0013493
Locus tag
b4119
See related
ECOCYC:EG10577
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4112; mel-7
Summary
Alpha-galactosidase was previously thought to be a tetramer, but is now believed to be a dimer. [More information is available at EcoCyc: EG10577].
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Genomic context

Sequence:
NC_000913.3 (4341911..4343266)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene arginine decarboxylase, degradative Neighboring gene DNA-binding transcriptional dual regulator MelR Neighboring gene melibiose:H(+)/Na(+)/Li(+) symporter Neighboring gene DUF2238 domain-containing inner membrane protein YjdF

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables NAD+ binding IDA
Inferred from Direct Assay
more info
PubMed 
enables alpha-galactosidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables alpha-galactosidase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
Inferred from Electronic Annotation
more info
 
enables manganese ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within melibiose catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
alpha-galactosidase
NP_418543.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4341911..4343266
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418543.1 alpha-galactosidase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418543.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2H4TRS8, A0A8S7CP62
    Conserved Domains (1) summary
    PRK15076
    Location:4449
    PRK15076; alpha-galactosidase; Provisional