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hokD Qin prophage; toxic protein HokD [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948616, updated on 6-May-2021

Summary

Gene symbol
hokD
Gene description
Qin prophage; toxic protein HokD
Primary source
ASAP:ABE-0005219
Locus tag
b1562
See related
ECOCYC:EG11130
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1556; relF
Summary
hokD regulatory elements are apparently deleted in K-12 and hokD is fused to relBE transcript. [More information is available at EcoGene: EG11130]. Sequence analysis indicates that the hokD gene is a homologue of the hok (host killing) gene which is responsible for mediating plasmid stabilization by post-segregational killing (PSK) in plasmid R1. hok encodes a stable mRNA whose translation is inhibited by a less stable mRNA encoded by sok. [More information is available at EcoCyc: EG11130].
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Genomic context

Sequence:
NC_000913.3 (1645119..1645274, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene Qin prophage; protein YdfU Neighboring gene Qin prophage; protein Rem Neighboring gene Qin prophage; mRNA interferase toxin RelE Neighboring gene Qin prophage; antitoxin/DNA-binding transcriptional repressor RelB

General gene information

Gene Ontology Provided by GO

Process Evidence Code Pubs
acts_upstream_of_or_within cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of plasma membrane RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Qin prophage; toxic protein HokD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1645119..1645274 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416080.1 Qin prophage; toxic protein HokD [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416080.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P0ACG6
    Conserved Domains (1) summary
    pfam01848
    Location:647
    HOK_GEF; Hok/gef family
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