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phnM [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948613, updated on 24-Aug-2024

Summary

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Official Symbol
phnM
Primary source
ECOCYC:EG10722
Locus tag
b4095
See related
ASAP:ABE-0013419
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4088
Summary
Phosphonate utilization is cryptic in K-12. [More information is available at EcoGene: EG10722]. phnM is a member of the 14-gene phnCDEFGHIJKLMNOP operon which is involved in phosphonate uptake and metabolism and is a member of the phosphate regulon . [More information is available at EcoCyc: EG10722].
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Genomic context

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Sequence:
NC_000913.3 (4316082..4317218, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene 5-phospho-alpha-D-ribosyl 1,2-cyclic phosphate phosphodiesterase Neighboring gene aminoalkylphosphonate N-acetyltransferase Neighboring gene ribose 1,5-bisphosphate phosphokinase Neighboring gene methylphosphonate degradation complex subunit PhnL Neighboring gene carbon-phosphorus lyase subunit PhnK Neighboring gene carbon-phosphorus lyase core complex subunit PhnJ Neighboring gene carbon-phosphorus lyase core complex subunit PhnI Neighboring gene carbon-phosphorus lyase core complex subunit PhnH

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Phosphate-independent expression of the carbon-phosphorus lyase activity of Escherichia coli. Yakovleva GM, et al. Appl Microbiol Biotechnol, 1998 May. PMID 9650256
  2. Genes for phosphonate biodegradation in Escherichia coli. Wanner BL. SAAS Bull Biochem Biotechnol, 1992 Jan. PMID 1368181
  3. Involvement of the Escherichia coli phn (psiD) gene cluster in assimilation of phosphorus in the form of phosphonates, phosphite, Pi esters, and Pi. Metcalf WW, et al. J Bacteriol, 1991 Jan. PMID 1846145, Free PMC Article
  4. MEROPS: the peptidase database. Rawlings ND, et al. Nucleic Acids Res, 2006 Jan 1. PMID 16381862, Free PMC Article
  5. Molecular genetic studies of a 10.9-kb operon in Escherichia coli for phosphonate uptake and biodegradation. Wanner BL, et al. FEMS Microbiol Lett, 1992 Dec 15. PMID 1335942

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in organic phosphonate catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within organic phosphonate catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
RPnTP hydrolase
NP_418519.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4316082..4317218 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418519.1 RPnTP hydrolase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418519.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A478LIN2
    Conserved Domains (1) summary
    COG3454
    Location:1 → 378
    PhnM; Alpha-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase PhnM [Inorganic ion transport and metabolism]
Nucleotide Protein
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