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CHST10 carbohydrate sulfotransferase 10 [ Homo sapiens (human) ]

Gene ID: 9486, updated on 1-Jun-2020

Summary

Official Symbol
CHST10provided by HGNC
Official Full Name
carbohydrate sulfotransferase 10provided by HGNC
Primary source
HGNC:HGNC:19650
See related
Ensembl:ENSG00000115526 MIM:606376
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HNK1ST; HNK-1ST
Summary
This protein encoded by this gene transfers sulfate to the C-3 hydroxyl of terminal glucuronic acid of protein- and lipid-linked oligosaccharides. This protein was first identified as a sulfotransferase that acts on the human natural killer-1 (HNK-1) glycan; HNK-1 is a carbohydrate involved in neurodevelopment and synaptic plasticity.[provided by RefSeq, Feb 2011]
Expression
Broad expression in brain (RPKM 10.4), endometrium (RPKM 4.2) and 21 other tissues See more
Orthologs

Genomic context

See CHST10 in Genome Data Viewer
Location:
2q11.2
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (100391860..100417668, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (101008322..101034130, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene LON peptidase N-terminal domain and ring finger 2 Neighboring gene CYCS pseudogene 7 Neighboring gene RALBP1 pseudogene 2 Neighboring gene uncharacterized LOC105373506 Neighboring gene neuromedin S

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env Sulfate is linked to the carbohydrate chains of HIV-1 glycoproteins gp160, gp120, and gp41 during the endoplasmic reticulum to Golgi transport of the glycoproteins PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC17148

Gene Ontology Provided by GOA

Function Evidence Code Pubs
HNK-1 sulfotransferase activity TAS
Traceable Author Statement
more info
 
sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
carbohydrate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
cell adhesion TAS
Traceable Author Statement
more info
PubMed 
proteoglycan biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus TAS
Traceable Author Statement
more info
PubMed 
Golgi membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
carbohydrate sulfotransferase 10
Names
HNK-1 sulfotransferase
huHNK-1ST
NP_004845.1
XP_011510509.1
XP_011510510.1
XP_011510512.1
XP_011510513.1
XP_016860869.1
XP_016860870.1
XP_016860871.1
XP_016860872.1
XP_024309016.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028153.1 RefSeqGene

    Range
    5001..30809
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_004854.5NP_004845.1  carbohydrate sulfotransferase 10 precursor

    See identical proteins and their annotated locations for NP_004845.1

    Status: REVIEWED

    Source sequence(s)
    AF033827, AF070594, DA522916, DA732392
    Consensus CDS
    CCDS2047.1
    UniProtKB/Swiss-Prot
    O43529
    Related
    ENSP00000264249.3, ENST00000264249.8
    Conserved Domains (1) summary
    pfam03567
    Location:116348
    Sulfotransfer_2; Sulfotransferase family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    100391860..100417668 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011512210.1XP_011510512.1  carbohydrate sulfotransferase 10 isoform X1

    See identical proteins and their annotated locations for XP_011510512.1

    UniProtKB/Swiss-Prot
    O43529
    Conserved Domains (1) summary
    pfam03567
    Location:116348
    Sulfotransfer_2; Sulfotransferase family
  2. XM_011512207.2XP_011510509.1  carbohydrate sulfotransferase 10 isoform X1

    See identical proteins and their annotated locations for XP_011510509.1

    UniProtKB/Swiss-Prot
    O43529
    Related
    ENSP00000387309.1, ENST00000409701.5
    Conserved Domains (1) summary
    pfam03567
    Location:116348
    Sulfotransfer_2; Sulfotransferase family
  3. XM_024453248.1XP_024309016.1  carbohydrate sulfotransferase 10 isoform X1

    Conserved Domains (1) summary
    pfam03567
    Location:116348
    Sulfotransfer_2; Sulfotransferase family
  4. XM_011512211.1XP_011510513.1  carbohydrate sulfotransferase 10 isoform X1

    See identical proteins and their annotated locations for XP_011510513.1

    UniProtKB/Swiss-Prot
    O43529
    Conserved Domains (1) summary
    pfam03567
    Location:116348
    Sulfotransfer_2; Sulfotransferase family
  5. XM_011512208.1XP_011510510.1  carbohydrate sulfotransferase 10 isoform X1

    See identical proteins and their annotated locations for XP_011510510.1

    UniProtKB/Swiss-Prot
    O43529
    Conserved Domains (1) summary
    pfam03567
    Location:116348
    Sulfotransfer_2; Sulfotransferase family
  6. XM_017005380.2XP_016860869.1  carbohydrate sulfotransferase 10 isoform X1

    UniProtKB/Swiss-Prot
    O43529
    Conserved Domains (1) summary
    pfam03567
    Location:116348
    Sulfotransfer_2; Sulfotransferase family
  7. XM_017005381.2XP_016860870.1  carbohydrate sulfotransferase 10 isoform X1

    UniProtKB/Swiss-Prot
    O43529
    Conserved Domains (1) summary
    pfam03567
    Location:116348
    Sulfotransfer_2; Sulfotransferase family
  8. XM_017005383.2XP_016860872.1  carbohydrate sulfotransferase 10 isoform X1

    UniProtKB/Swiss-Prot
    O43529
    Conserved Domains (1) summary
    pfam03567
    Location:116348
    Sulfotransfer_2; Sulfotransferase family
  9. XM_017005382.2XP_016860871.1  carbohydrate sulfotransferase 10 isoform X1

    UniProtKB/Swiss-Prot
    O43529
    Conserved Domains (1) summary
    pfam03567
    Location:116348
    Sulfotransfer_2; Sulfotransferase family
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