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ssb ssDNA-binding protein [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948570, updated on 11-Oct-2018

Summary

Gene symbol
ssb
Gene description
ssDNA-binding protein
Primary source
EcoGene:EG10976
Locus tag
b4059
See related
ASAP:ABE-0013298; ECOCYC:EG10976
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4051; exrB; lexC
Summary
SSB binds to RecQ and stimulates DNA unwinding (Shereda, 2007). [More information is available at EcoGene: EG10976]. The product of the essential ssb gene, the highly stable single-stranded DNA binding protein SSB, is involved in replication, recombination, and repair in the DNA metabolism of Escherichia coli. [More information is available at EcoCyc: EG10976].

Genomic context

Sequence:
NC_000913.3 (4274125..4274661)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene PF04237 family protein YjbR Neighboring gene excision nuclease subunit A Neighboring gene uncharacterized protein YjcB Neighboring gene c-di-GMP phosphodiesterase PdeC

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • DNA replication, organism-specific biosystem (from KEGG)
    DNA replication, organism-specific biosystemA complex network of interacting proteins and enzymes is required for DNA replication. Generally, DNA replication follows a multistep enzymatic pathway. At the DNA replication fork, a DNA helicase (D...
  • DNA replication, conserved biosystem (from KEGG)
    DNA replication, conserved biosystemA complex network of interacting proteins and enzymes is required for DNA replication. Generally, DNA replication follows a multistep enzymatic pathway. At the DNA replication fork, a DNA helicase (D...
  • Homologous recombination, organism-specific biosystem (from KEGG)
    Homologous recombination, organism-specific biosystemHomologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves...
  • Homologous recombination, conserved biosystem (from KEGG)
    Homologous recombination, conserved biosystemHomologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves...
  • Mismatch repair, organism-specific biosystem (from KEGG)
    Mismatch repair, organism-specific biosystemDNA mismatch repair (MMR) is a highly conserved biological pathway that plays a key role in maintaining genomic stability. MMR corrects DNA mismatches generated during DNA replication, thereby preven...
  • Mismatch repair, conserved biosystem (from KEGG)
    Mismatch repair, conserved biosystemDNA mismatch repair (MMR) is a highly conserved biological pathway that plays a key role in maintaining genomic stability. MMR corrects DNA mismatches generated during DNA replication, thereby preven...

General gene information

Gene Ontology Provided by GO

Function Evidence Code Pubs
enzyme activator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
single-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
SOS response TAS
Traceable Author Statement
more info
PubMed 
mismatch repair TAS
Traceable Author Statement
more info
PubMed 
positive regulation of catalytic activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
recombinational repair TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
nucleoid IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4274125..4274661
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418483.1 ssDNA-binding protein [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418483.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P0AGE0
    Conserved Domains (1) summary
    PRK09010
    Location:1178
    PRK09010; single-stranded DNA-binding protein; Provisional
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