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zur DNA-binding transcriptional repressor Zur [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948552, updated on 23-Apr-2026
Official Symbol
zur
Official Full Name
DNA-binding transcriptional repressor Zur
Primary source
ECOCYC:EG11929
Locus tag
b4046
See related
ASAP:ABE-0013249
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4038; yjbK; znuR
Summary
Although the N-terminal sequence was derived from a vector with an artificial RBS, Patzer and Hantke (2000) demonstrate that the second ATG is the correct start. [More information is available at EcoGene: EG11929].
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Sequence:
NC_000913.3 (4259488..4260003, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA damage-inducible protein F Neighboring gene putative stress response protein YjbJ Neighboring gene uncharacterized protein YjbL Neighboring gene DUF2713 domain-containing protein YjbM

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Biphasic unbinding of a metalloregulator from DNA for transcription (de)repression in Live Bacteria. Jung W, et al. Nucleic Acids Res, 2020 Mar 18. PMID 32009151, Free PMC Article
  2. Characterization of the metal receptor sites in Escherichia coli Zur, an ultrasensitive zinc(II) metalloregulatory protein. Outten CE, et al. Biochemistry, 2001 Sep 4. PMID 11523983
  3. Structural and mechanistic basis of zinc regulation across the E. coli Zur regulon. Gilston BA, et al. PLoS Biol, 2014 Nov. PMID 25369000, Free PMC Article
  4. Simulating in vitro transcriptional response of zinc homeostasis system in Escherichia coli. Cui J, et al. BMC Syst Biol, 2008 Oct 24. PMID 18950480, Free PMC Article
  5. Transcriptional response of Escherichia coli to TPEN. Sigdel TK, et al. J Bacteriol, 2006 Sep. PMID 16952965, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In live Escherichia coli cells, Zur's unbinding rate from DNA is sensitive to Zur protein concentration in a first-of-its-kind biphasic manner, initially impeded and then facilitated with increasing Zur concentration.
    Title: Biphasic unbinding of a metalloregulator from DNA for transcription (de)repression in Live Bacteria.
  2. pliG is directly regulated by Zur in a zinc responsive manner
    Title: Structural and mechanistic basis of zinc regulation across the E. coli Zur regulon.
  3. N-terminus verified by Edman degradation on complete protein
    Title: The zinc-responsive regulator Zur and its control of the znu gene cluster encoding the ZnuABC zinc uptake system in Escherichia coli.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription repressor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription cis-regulatory region binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription cis-regulatory region binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of secondary metabolite biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein-DNA complex IPI
Inferred from Physical Interaction
more info
 PubMed 
Preferred Names
DNA-binding transcriptional repressor Zur

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4259488..4260003 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418470.4 DNA-binding transcriptional repressor Zur

    See identical proteins and their annotated locations for NP_418470.4

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A5N8HH94
    Conserved Domains (1) summary
    PRK11639
    Location:1 → 169
    PRK11639; zinc uptake transcriptional repressor Zur
Nucleotide Protein
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