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lamB maltose outer membrane channel/phage lambda receptor protein [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948548, updated on 6-Jul-2026
Official Symbol
lamB
Official Full Name
maltose outer membrane channel/phage lambda receptor protein
Primary source
ECOCYC:EG10528
Locus tag
b4036
See related
ASAP:ABE-0013218
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4028; malB; malL
Summary
LamB also facilitates the diffusion of maltooligosaccharides, i.e maltodextrin. [More information is available at EcoGene: EG10528]. LamB is a member of the Sugar Porin (SP) family. [More information is available at EcoCyc: EG10528].
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Sequence:
NC_000913.3 (4247971..4249311)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene maltose ABC transporter periplasmic binding protein Neighboring gene maltose ABC transporter ATP binding subunit Neighboring gene maltose regulon periplasmic protein Neighboring gene pseudo

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Negative dominance in gene lamB: random assembly of secreted subunits issued from different polysomes. Marchal C, et al. EMBO J, 1983. PMID 11894914, Free PMC Article
  2. Channel specificity: structural basis for sugar discrimination and differential flux rates in maltoporin. Wang YF, et al. J Mol Biol, 1997 Sep 12. PMID 9299337
  3. Bioaccumulation of heavy metals with protein fusions of metallothionein to bacterial OMPs. Valls M, et al. Biochimie, 1998 Oct. PMID 9893944
  4. Acarbose, a pseudooligosaccharide, is transported but not metabolized by the maltose-maltodextrin system of Escherichia coli. Brunkhorst C, et al. J Bacteriol, 1999 Apr. PMID 10198028, Free PMC Article
  5. Orientation of LamB signal peptides in bilayers: influence of lipid probes on peptide binding and interpretation of fluorescence quenching data. Voglino L, et al. Biochemistry, 1999 Jun 8. PMID 10360948

See all (85) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LamB, OmpC, and the Core Lipopolysaccharide of Escherichia coli K-12 Function as Receptors of Bacteriophage Bp7.
    Title: LamB, OmpC, and the Core Lipopolysaccharide of Escherichia coli K-12 Function as Receptors of Bacteriophage Bp7.
  2. Our data indicate that the negative regulation by LamB is widely detected in antibiotic-resistant E. coli. LamB serves as a porin to influx an antibiotic and is interacted with Odp1.
    Title: Decreased expression of LamB and Odp1 complex is crucial for antibiotic resistance in Escherichia coli.
  3. Elevated expression of LamB causes cell death when the osmoregulator OmpR is disabled.
    Title: Constitutive expression of the maltoporin LamB in the absence of OmpR damages the cell envelope.
  4. Results report the crystallization of E. coli maltoporin in a new crystal form; the crystals belonged to the trigonal R3 space group and diffracted to 1.9 A resolution.
    Title: Crystallization of Escherichia coli maltoporin in the trigonal space group R3.
  5. downregulation of LamB expression in the CTC-resistant E. coli strain and the increased antibiotic resistance in its gene-deleted strain suggested a negative regulation mechanism in E. coli in response to CTC
    Title: A novel negative regulation mechanism of bacterial outer membrane proteins in response to antibiotic resistance.
  6. Data report that cells lacking OmpR and harboring constitutively active MalT undergo premature death that involves increased expression of the outer membrane porin LamB.
    Title: A critical process controlled by MalT and OmpR is revealed through synthetic lethality.
  7. N-terminus verified by Edman degradation on mature peptide
    Title: Major proteins of the Escherichia coli outer cell envelope membrane. Preliminary characterization of the phage lambda receptor protein.
  8. all aromatic residues provide some steric hindrance for ion transport through LamB
    Title: Site-directed mutagenesis of the greasy slide aromatic residues within the LamB (maltoporin) channel of Escherichia coli: effect on ion and maltopentaose transport.
  9. demonstrated that LamB moves along the bacterial surface and that these movements are restricted by an underlying dynamic spiral pattern
    Title: Complex spatial distribution and dynamics of an abundant Escherichia coli outer membrane protein, LamB.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables carbohydrate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables maltodextrin transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables maltodextrin transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables maltose transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables maltose transporting porin activity IEA
Inferred from Electronic Annotation
more info
  
enables porin activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables porin activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables porin activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables virus receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in carbohydrate transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in maltodextrin transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in maltodextrin transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in maltose transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in maltose transport IEA
Inferred from Electronic Annotation
more info
  
involved_in polysaccharide transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in symbiont entry into host cell IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell outer membrane EXP
Inferred from Experiment
more info
 PubMed 
is_active_in cell outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of outer membrane protein complex IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
maltose outer membrane channel/phage lambda receptor protein

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4247971..4249311
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418460.1 maltose outer membrane channel/phage lambda receptor protein

    See identical proteins and their annotated locations for NP_418460.1

    Status: REVIEWED

    Conserved Domains (1) summary
    PRK09360
    Location:1 → 446
    lamB; maltoporin LamB
Nucleotide Protein
Heading Accession and Version

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