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ubiC chorismate lyase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948545, updated on 30-Jul-2025
Official Symbol
ubiC
Official Full Name
chorismate lyase
Primary source
ECOCYC:EG11369
Locus tag
b4039
See related
ASAP:ABE-0013227
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4031
Summary
Chorismate pyruvate lyase catalyzes the first committed step in the biosynthesis of ubiquinone, the conversion of chorismate to 4-hydroxybenzoate . [More information is available at EcoCyc: EG11369].
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Sequence:
NC_000913.3 (4252506..4253003)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene maltose regulon periplasmic protein Neighboring gene pseudo Neighboring gene 4-hydroxybenzoate octaprenyltransferase Neighboring gene glycerol-3-phosphate 1-O-acyltransferase

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Biosynthesis of ubiquinone in Escherichia coli K-12: biochemical and genetic characterization of a mutant unable to convert chorismate into 4-hydroxybenzoate. Lawrence J, et al. J Bacteriol, 1974 Apr. PMID 4595202, Free PMC Article
  2. Structural analysis of ligand binding and catalysis in chorismate lyase. Smith N, et al. Arch Biochem Biophys, 2006 Jan 1. PMID 16343413
  3. Aerobic and anaerobic regulation of the ubiCA operon, encoding enzymes for the first two committed steps of ubiquinone biosynthesis in Escherichia coli. Søballe B, et al. FEBS Lett, 1997 Sep 8. PMID 9315722
  4. Crystallization and 1.1-A diffraction of chorismate lyase from Escherichia coli. Stover C, et al. J Struct Biol, 2000 Feb. PMID 10675300
  5. Chorismate lyase: kinetics and engineering for stability. Holden MJ, et al. Biochim Biophys Acta, 2002 Jan 31. PMID 11825618

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on mature peptide
    Title: Cloning and sequencing of Escherichia coli ubiC and purification of chorismate lyase.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables chorismate lyase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chorismate lyase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables chorismate lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables chorismate lyase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in pyruvate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquinone biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquinone biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within ubiquinone biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
chorismate lyase
NP_418463.4

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4252506..4253003
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418463.4 chorismate lyase

    See identical proteins and their annotated locations for NP_418463.4

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A775YUH4
    Conserved Domains (1) summary
    PRK11655
    Location:1 → 165
    ubiC; chorismate pyruvate lyase; Provisional
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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