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lexA DNA-binding transcriptional repressor LexA [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948544, updated on 18-Sep-2021

Summary

Gene symbol
lexA
Gene description
DNA-binding transcriptional repressor LexA
Primary source
ASAP:ABE-0013241
Locus tag
b4043
See related
ECOCYC:EG10533
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4035; exrA; spr; tsl; umuA
Summary
LexA autocleavage, stimulated by RecA, of the first 84 aa of LexA removes the DNA binding region and is required to activate the SOS response. [More information is available at EcoGene: EG10533]. LexA is a protein that belongs to the LexA family . [More information is available at EcoCyc: EG10533].
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Genomic context

Sequence:
NC_000913.3 (4257115..4257723)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene glycerol-3-phosphate 1-O-acyltransferase Neighboring gene diacylglycerol kinase Neighboring gene DNA damage-inducible protein F Neighboring gene putative stress response protein YjbJ

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription repressor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription repressor activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables transcription cis-regulatory region binding IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription cis-regulatory region binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within DNA replication IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within SOS response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within SOS response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular response to DNA damage stimulus IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cellular response to DNA damage stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription, DNA-templated EXP
Inferred from Experiment
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of transcription, DNA-templated IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-DNA complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-DNA complex IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
DNA-binding transcriptional repressor LexA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4257115..4257723
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418467.1 DNA-binding transcriptional repressor LexA [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418467.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P0A7C2
    Conserved Domains (1) summary
    PRK00215
    Location:3199
    PRK00215; transcriptional repressor LexA
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